8WSS

Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH

Summary for 8WSS

• Entry DOI: 10.2210/pdb8wss/pdb
• EMDB information: 37823
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: melanin-concentrating hormone receptors1, gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 165802.74

Authors

Zhao, L.,He, Q.,Yuan, Q.,Gu, Y.,Shan, H.,Hu, W.,Wu, K.,Xu, H.E.,Zhang, Y.,Wu, C. (deposition date: 2023-10-17, release date: 2024-06-19)

• Primary citation: He, Q.,Yuan, Q.,Shan, H.,Wu, C.,Gu, Y.,Wu, K.,Hu, W.,Zhang, Y.,He, X.,Xu, H.E.,Zhao, L.H.; Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors; Cell Discov, 10:48-, 2024; DOI: 10.1038/s41421-024-00679-8

Experimental method

ELECTRON MICROSCOPY (3.01 Å)