8WSS
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 | |
| B | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY80-THR102 | |
| A | ASN269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 53 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY103-PHE116 | |
| R | GLU182-ASP209 | |
| R | TRP276-PRO289 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | GLY117-LYS139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 77 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU140-ASP158 | |
| R | ILE233-ARG252 | |
| R | GLN313-ARG353 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU159-GLY181 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | ARG210-VAL232 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU253-TYR275 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | PHE290-SER312 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS351 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824 |
| Chain | Residue | Details |
| A | CYS3 |
