8WSS
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41055.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | H | Scfv16 | polymer | 285 | 30363.0 | 1 | Mus musculus | ||
5 | L | Pro-MCH | polymer | 19 | 2391.9 | 1 | UniProt (P20382) In PDB | Homo sapiens (human) | |
6 | R | Melanin-concentrating hormone receptor 1 | polymer | 402 | 43716.8 | 1 | UniProt (Q99705) Pfam (PF00001) In PDB | Homo sapiens (human) | MCH receptor 1,MCH-R1,MCHR-1,G-protein coupled receptor 24,MCH-1R,MCH1R,MCHR,SLC-1,Somatostatin receptor-like protein |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: 70 - 405 (UniProt: Q99705)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gln 66 | - | expression tag |
Gly 67 | - | expression tag |
Gly 68 | - | expression tag |
Thr 69 | - | expression tag |
Gly 406 | - | expression tag |
Ser 407 | - | expression tag |
Ser 408 | - | expression tag |
Gly 409 | - | expression tag |
Gly 410 | - | expression tag |
Gly 411 | - | expression tag |
Gly 412 | - | expression tag |
Ser 413 | - | expression tag |
Gly 414 | - | expression tag |
Gly 415 | - | expression tag |
Gly 416 | - | expression tag |
Gly 417 | - | expression tag |
Ser 418 | - | expression tag |
Ser 419 | - | expression tag |
Gly 420 | - | expression tag |
Val 421 | - | expression tag |
Phe 422 | - | expression tag |
Thr 423 | - | expression tag |
Leu 424 | - | expression tag |
Glu 425 | - | expression tag |
Asp 426 | - | expression tag |
Phe 427 | - | expression tag |
Val 428 | - | expression tag |
Gly 429 | - | expression tag |
Asp 430 | - | expression tag |
Trp 431 | - | expression tag |
Glu 432 | - | expression tag |
Gln 433 | - | expression tag |
Thr 434 | - | expression tag |
Ala 435 | - | expression tag |
Ala 436 | - | expression tag |
Tyr 437 | - | expression tag |
Asn 438 | - | expression tag |
Leu 439 | - | expression tag |
Asp 440 | - | expression tag |
Gln 441 | - | expression tag |
Val 442 | - | expression tag |
Leu 443 | - | expression tag |
Glu 444 | - | expression tag |
Gln 445 | - | expression tag |
Gly 446 | - | expression tag |
Gly 447 | - | expression tag |
Val 448 | - | expression tag |
Ser 449 | - | expression tag |
Ser 450 | - | expression tag |
Leu 451 | - | expression tag |
Leu 452 | - | expression tag |
Gln 453 | - | expression tag |
Asn 454 | - | expression tag |
Leu 455 | - | expression tag |
Ala 456 | - | expression tag |
Val 457 | - | expression tag |
Ser 458 | - | expression tag |
Val 459 | - | expression tag |
Thr 460 | - | expression tag |
Pro 461 | - | expression tag |
Ile 462 | - | expression tag |
Gln 463 | - | expression tag |
Arg 464 | - | expression tag |
Ile 465 | - | expression tag |
Val 466 | - | expression tag |
Arg 467 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 165802.7 | |
All* | Total formula weight | 165802.7 |