7JNI

Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401

Summary for 7JNI

Entry DOI	10.2210/pdb7jni/pdb
Descriptor	Soluble cytochrome b562,Type-2 angiotensin II receptor, Olodanrigan, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (7 entities in total)
Functional Keywords	angiotensin ii type 2 receptor, at2r, ema401, pd-126055, g protein-coupled receptor, gpcr, bril fusion, glioblastoma, gbm, membrane protein, lcp
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	96734.20
Authors	Cherezov, V.,Shaye, H.,Han, G.W. (deposition date: 2020-08-04, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Perryman, R.,Renziehausen, A.,Shaye, H.,Kostagianni, A.D.,Tsiailanis, A.D.,Thorne, T.,Chatziathanasiadou, M.V.,Sivolapenko, G.B.,El Mubarak, M.A.,Han, G.W.,Zarzycka, B.,Katritch, V.,Lebon, G.,Lo Nigro, C.,Lattanzio, L.,Morse, S.V.,Choi, J.J.,O'Neill, K.,Kanaki, Z.,Klinakis, A.,Crook, T.,Cherezov, V.,Tzakos, A.G.,Syed, N. Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma. Proc.Natl.Acad.Sci.USA, 119:e2116289119-e2116289119, 2022 Cited by PubMed: 35917342 DOI: 10.1073/pnas.2116289119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation