7JNI
Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004945 | molecular_function | angiotensin type II receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0097746 | biological_process | blood vessel diameter maintenance |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004945 | molecular_function | angiotensin type II receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0042981 | biological_process | regulation of apoptotic process |
| B | 0097746 | biological_process | blood vessel diameter maintenance |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfFITCMSVDRYQsV |
| Chain | Residue | Details |
| A | ALA130-VAL146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 102 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 90 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
