6XM2
 
 | | The structure of the 4A11.v7 antibody in complex with human TGFb2 | | Descriptor: | 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2 | | Authors: | Lupardus, P.J, Yin, J.P. | | Deposit date: | 2020-06-29 | | Release date: | 2021-07-07 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med, 13, 2021
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6ZQS
 | | Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) | | Descriptor: | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 14 | | Authors: | Kirsch, K, Sok, P, Poti, A.L, Remenyi, A. | | Deposit date: | 2020-07-10 | | Release date: | 2020-11-18 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Nat Commun, 11, 2020
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6ZUI
 | | Crystal structure of the Cys-Ser mutant of the cpYFP-based biosensor for hypochlorous acid | | Descriptor: | HTH-type transcriptional repressor NemR,Green fluorescent protein,Green fluorescent protein,HTH-type transcriptional repressor NemR | | Authors: | Tossounian, M.A, Van Molle, I, Messens, J. | | Deposit date: | 2020-07-23 | | Release date: | 2021-06-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.200082 Å) | | Cite: | Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives.
Nat Commun, 13, 2022
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8FXS
 | | Crystal structure of human pro-TGF-beta2 in complex with Nb9 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 9, Transforming growth factor beta-2 proprotein | | Authors: | Le, V.Q, Springer, T.A. | | Deposit date: | 2023-01-25 | | Release date: | 2023-06-21 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8VS6
 | | L-TGF-b3/avb8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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8FXV
 | | Crystal structure of human proTGF-beta2 in complex with Nb18 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 18, Transforming growth factor beta-2 proprotein | | Authors: | Le, V.Q, Springer, T.A. | | Deposit date: | 2023-01-25 | | Release date: | 2023-06-21 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8VSB
 | | L-TGF-b3/GARP | | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-3 proprotein | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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7UXH
 | | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Cui, Z, Hurley, J. | | Deposit date: | 2022-05-05 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
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7UXC
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6GCU
 | | MET receptor in complex with InlB internalin domain and DARPin A3A | | Descriptor: | DARPin A3A, Hepatocyte growth factor receptor, Internalin B | | Authors: | Meyer, T, Andres, F, Iamele, L, Gherardi, E, Pluckthun, A, Niemann, H.H. | | Deposit date: | 2018-04-19 | | Release date: | 2019-05-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (6.001 Å) | | Cite: | Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
J.Mol.Biol., 431, 2019
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7XUZ
 | | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | | Descriptor: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | | Authors: | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | | Deposit date: | 2022-05-20 | | Release date: | 2023-11-29 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (3.591 Å) | | Cite: | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
Nucleic Acids Res., 52, 2024
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4WV1
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6MGN
 | | mouse Id1 (51-104) - human hE47 (348-399) complex | | Descriptor: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | | Authors: | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | | Deposit date: | 2018-09-14 | | Release date: | 2019-09-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Cell Rep, 29, 2019
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6BCU
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6BCX
 | | mTORC1 structure refined to 3.0 angstroms | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | | Authors: | Pavletich, N.P, Yang, H. | | Deposit date: | 2017-10-20 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
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6YDP
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6YDW
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6LOS
 | | Crystal structure of mouse PEDF in complex with heterotrimeric collagen model peptide. | | Descriptor: | Collagen model peptide, type I, alpha 1, ... | | Authors: | Kawahara, K, Maruno, T, Oki, H, Yoshida, T, Ohkubo, T, Koide, T, Kobayashi, Y. | | Deposit date: | 2020-01-07 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.476 Å) | | Cite: | Spatiotemporal regulation of PEDF signaling by type I collagen remodeling.
Proc.Natl.Acad.Sci.USA, 117, 2020
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3OUX
 | | Structure of beta-catenin with phosphorylated Lef-1 | | Descriptor: | Catenin beta-1, Lymphoid enhancer-binding factor 1 | | Authors: | Weis, W.I, Sun, J. | | Deposit date: | 2010-09-15 | | Release date: | 2010-11-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Biochemical and structural characterization of beta-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1.
J.Mol.Biol., 405, 2011
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8ONS
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3OUW
 | | Structure of beta-catenin with Lef-1 | | Descriptor: | Catenin beta-1, Lymphoid enhancer-binding factor 1 | | Authors: | Weis, W.I, Sun, J. | | Deposit date: | 2010-09-15 | | Release date: | 2010-11-24 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.91 Å) | | Cite: | Biochemical and structural characterization of beta-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1.
J.Mol.Biol., 405, 2011
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1G0D
 | | CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE | | Descriptor: | PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE, SULFATE ION | | Authors: | Noguchi, K, Ishikawa, K, Yokoyama, K, Ohtsuka, T, Nio, N, Suzuki, E. | | Deposit date: | 2000-10-06 | | Release date: | 2001-05-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of red sea bream transglutaminase.
J.Biol.Chem., 276, 2001
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8VSD
 | | avb8/L-TGF-b1/GARP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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8VSC
 | | L-TGF-b1/GARP | | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-1 proprotein | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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7T2L
 | | Crystal Structure of TEAD2 in a covalent complex with TED-662 | | Descriptor: | (3aR,4R,7aS)-4-[3-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile, Transcriptional enhancer factor TEF-4 | | Authors: | Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O. | | Deposit date: | 2021-12-05 | | Release date: | 2023-06-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.
J.Med.Chem., 66, 2023
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