4WV1

Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3

Summary for 4WV1

DescriptorFibroblast growth factor receptor 2, Fab heavy chain, Fab light chain, ... (4 entities in total)
Functional Keywordsfgfr2, fab, complex, antibody, transferase-immune system complex, transferase/immune system
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802
Total number of polymer chains6
Total molecular weight118294.05
Authors
Yin, Y.,Carter, P.J. (deposition date: 2014-11-04, release date: 2015-09-16, Last modification date: 2015-10-14)
Primary citation
Yin, Y.,Djakovic, S.,Marsters, S.,Tien, J.,Peng, J.,Tremayne, J.,Lee, G.,Neve, R.M.,Wu, Y.,Merchant, M.,Ashkenazi, A.,Carter, P.J.
Redesigning a Monospecific Anti-FGFR3 Antibody to Add Selectivity for FGFR2 and Expand Antitumor Activity.
Mol.Cancer Ther., 14:2270-2278, 2015
PubMed: 26269606 (PDB entries with the same primary citation)
DOI: 10.1158/1535-7163.MCT-14-1050
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.362 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24460.2%2.9%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report