6BCU

Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom

This is a non-PDB format compatible entry.

Summary for 6BCU

• Entry DOI: 10.2210/pdb6bcu/pdb
• Related: 6BCX
• EMDB information: 7086
• Descriptor: Serine/threonine-protein kinase mTOR,Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR,Regulatory-associated protein of mTOR, ... (8 entities in total)
• Functional Keywords: pikk, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 1016877.32

Authors

Pavletich, N.P.,Yang, H. (deposition date: 2017-10-20, release date: 2017-12-20, Last modification date: 2024-03-13)

• Primary citation: Yang, H.,Jiang, X.,Li, B.,Yang, H.J.,Miller, M.,Yang, A.,Dhar, A.,Pavletich, N.P.; Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.; Nature, 552:368-373, 2017; PubMed: 29236692; DOI: 10.1038/nature25023

Experimental method

ELECTRON MICROSCOPY (3.8 Å)