6ZQS

Crystal structure of double-phosphorylated p38alpha with ATF2(83-102)

Summary for 6ZQS

Entry DOI	10.2210/pdb6zqs/pdb
Descriptor	Mitogen-activated protein kinase 14, Cyclic AMP-dependent transcription factor ATF-2, 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, ... (4 entities in total)
Functional Keywords	transcription, mapk signaling pathways
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	44374.17
Authors	Kirsch, K.,Sok, P.,Poti, A.L.,Remenyi, A. (deposition date: 2020-07-10, release date: 2020-11-18, Last modification date: 2024-01-31)
Primary citation	Kirsch, K.,Zeke, A.,Toke, O.,Sok, P.,Sethi, A.,Sebo, A.,Kumar, G.S.,Egri, P.,Poti, A.L.,Gooley, P.,Peti, W.,Bento, I.,Alexa, A.,Remenyi, A. Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11:5769-5769, 2020 Cited by PubMed: 33188182 DOI: 10.1038/s41467-020-19582-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation