6ZQS
Crystal structure of double-phosphorylated p38alpha with ATF2(83-102)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 362 | 41647.3 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (Human) | MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
| 2 | B (B) | Cyclic AMP-dependent transcription factor ATF-2 | polymer | 20 | 2301.5 | 1 | UniProt (P15336) | Homo sapiens | cAMP-dependent transcription factor ATF-2,Activating transcription factor 2,Cyclic AMP-responsive element-binding protein 2,cAMP-responsive element-binding protein 2,HB16,Histone acetyltransferase ATF2,cAMP response element-binding protein CRE-BP1 |
| 3 | C (A) | 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | non-polymer | 425.4 | 1 | Chemie (3FF) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 351 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
B: 83 - 102 (UniProt: P15336)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 90 | Ser 90 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43948.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 425.4 | |
| All* | Total formula weight | 44374.2 |
