6XM2

The structure of the 4A11.v7 antibody in complex with human TGFb2

Summary for 6XM2

• Entry DOI: 10.2210/pdb6xm2/pdb
• Descriptor: 4A11.v7 kappa light chain Fab (VL-CL) humanized, 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, Transforming growth factor beta-2, ... (4 entities in total)
• Functional Keywords: tgfb antibody, cytokine, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 243111.78

Authors

Lupardus, P.J.,Yin, J.P. (deposition date: 2020-06-29, release date: 2021-07-07, Last modification date: 2023-10-18)

• Primary citation: Sun, T.,Huang, Z.,Liang, W.C.,Yin, J.,Lin, W.Y.,Wu, J.,Vernes, J.M.,Lutman, J.,Caplazi, P.,Jeet, S.,Wong, T.,Wong, M.,DePianto, D.J.,Morshead, K.B.,Sun, K.H.,Modrusan, Z.,Vander Heiden, J.A.,Abbas, A.R.,Zhang, H.,Xu, M.,N'Diaye, E.N.,Roose-Girma, M.,Wolters, P.J.,Yadav, R.,Sukumaran, S.,Ghilardi, N.,Corpuz, R.,Emson, C.,Meng, Y.G.,Ramalingam, T.R.,Lupardus, P.,Brightbill, H.D.,Seshasayee, D.,Wu, Y.,Arron, J.R.; TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.; Sci Transl Med, 13:-, 2021; PubMed: 34349032; DOI: 10.1126/scitranslmed.abe0407

Experimental method

X-RAY DIFFRACTION (1.91 Å)