7XUZ

Crystal structure of a HDAC4-MEF2A-DNA ternary complex

Summary for 7XUZ

• Entry DOI: 10.2210/pdb7xuz/pdb
• Descriptor: Histone deacetylase 4, myocyte-specific enhancer factor 2A isoform X4, DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), ... (4 entities in total)
• Functional Keywords: hdac4, mef2, transcription repressor, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 96089.67

Authors

Dai, S.Y.,Guo, L.,Dey, R.,Guo, M.,Bates, D.,Cayford, J.,Chen, X.J.,Wei, X.D.,Chen, L.,Chen, Y.H. (deposition date: 2022-05-20, release date: 2023-11-29, Last modification date: 2024-06-12)

• Primary citation: Dai, S.,Guo, L.,Dey, R.,Guo, M.,Zhang, X.,Bates, D.,Cayford, J.,Jiang, L.,Wei, H.,Chen, Z.,Zhang, Y.,Chen, L.,Chen, Y.; Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.; Nucleic Acids Res., 52:2711-2723, 2024; PubMed: 38281192; DOI: 10.1093/nar/gkae036

Experimental method

X-RAY DIFFRACTION (3.591 Å)