1XFU
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![BU of 1xfu by Molmil](/molmil-images/mine/1xfu) | Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin | Descriptor: | CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ... | Authors: | Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. | Deposit date: | 2004-09-15 | Release date: | 2005-05-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
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5WOB
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![BU of 5wob by Molmil](/molmil-images/mine/5wob) | Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin | Descriptor: | IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ... | Authors: | McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J. | Deposit date: | 2017-08-01 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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5UOE
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![BU of 5uoe by Molmil](/molmil-images/mine/5uoe) | |
3TN2
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![BU of 3tn2 by Molmil](/molmil-images/mine/3tn2) | structure analysis of MIP1-beta P8A | Descriptor: | C-C motif chemokine 4, ZINC ION | Authors: | Guo, Q, Tang, W.J. | Deposit date: | 2011-09-01 | Release date: | 2012-09-05 | Last modified: | 2018-08-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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3QZ2
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![BU of 3qz2 by Molmil](/molmil-images/mine/3qz2) | The structure of cysteine-free human insulin degrading enzyme | Descriptor: | Insulin-degrading enzyme, ZINC ION | Authors: | Guo, Q, Tang, W.J. | Deposit date: | 2011-03-04 | Release date: | 2012-01-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4RE9
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![BU of 4re9 by Molmil](/molmil-images/mine/4re9) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ... | Authors: | Liang, W.G, Deprez, R, Deprez, B, Tang, W.J. | Deposit date: | 2014-09-22 | Release date: | 2015-09-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.908 Å) | Cite: | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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4NGE
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![BU of 4nge by Molmil](/molmil-images/mine/4nge) | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | Descriptor: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | Authors: | King, J.V, Liang, W.G, Tang, W.J. | Deposit date: | 2013-11-01 | Release date: | 2014-05-14 | Last modified: | 2014-07-23 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22, 2014
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4RA8
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![BU of 4ra8 by Molmil](/molmil-images/mine/4ra8) | Structure analysis of the Mip1a P8A mutant | Descriptor: | C-C motif chemokine 3 | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | Deposit date: | 2014-09-09 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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4RAL
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![BU of 4ral by Molmil](/molmil-images/mine/4ral) | Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta | Descriptor: | C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION | Authors: | Liang, W.G, Ren, M, Guo, Q, Tang, W.J. | Deposit date: | 2014-09-10 | Release date: | 2015-05-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.148 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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4RPU
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![BU of 4rpu by Molmil](/molmil-images/mine/4rpu) | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 | Descriptor: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | Authors: | Mo, S.M, Liang, W.G, King, J.V, Wijaya, J, Koehler, C.M, Tang, W.J. | Deposit date: | 2014-10-31 | Release date: | 2015-12-09 | Method: | X-RAY DIFFRACTION (2.265 Å) | Cite: | Crystal Structure of Human Presequence Protease in Complex with Inhibitor MitoBloCK-60 TO BE PUBLISHED
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4QIA
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![BU of 4qia by Molmil](/molmil-images/mine/4qia) | Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine | Descriptor: | Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2014-05-30 | Release date: | 2015-05-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.202 Å) | Cite: | Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90, 2015
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5CJO
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4IOF
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![BU of 4iof by Molmil](/molmil-images/mine/4iof) | Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE) | Descriptor: | Fab-bound IDE, heavy chain, light chain, ... | Authors: | McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J. | Deposit date: | 2013-01-07 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.353 Å) | Cite: | Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc.Natl.Acad.Sci.USA, 110, 2013
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4L3T
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![BU of 4l3t by Molmil](/molmil-images/mine/4l3t) | Crystal Structure of Substrate-free Human Presequence Protease | Descriptor: | ACETATE ION, GLYCEROL, Presequence protease, ... | Authors: | King, J.V, Liang, W.G, Tang, W.J. | Deposit date: | 2013-06-06 | Release date: | 2013-07-03 | Last modified: | 2014-07-23 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22, 2014
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4DTT
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![BU of 4dtt by Molmil](/molmil-images/mine/4dtt) | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | Descriptor: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-21 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4DWK
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![BU of 4dwk by Molmil](/molmil-images/mine/4dwk) | Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-24 | Release date: | 2013-04-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4GS8
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![BU of 4gs8 by Molmil](/molmil-images/mine/4gs8) | Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid | Descriptor: | Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-08-27 | Release date: | 2013-08-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4GSC
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![BU of 4gsc by Molmil](/molmil-images/mine/4gsc) | Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-08-27 | Release date: | 2013-08-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4GSF
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![BU of 4gsf by Molmil](/molmil-images/mine/4gsf) | The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-08-27 | Release date: | 2013-08-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90, 2015
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1PK0
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![BU of 1pk0 by Molmil](/molmil-images/mine/1pk0) | Crystal Structure of the EF3-CaM complexed with PMEApp | Descriptor: | (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... | Authors: | Shen, Y, Tang, W.J. | Deposit date: | 2003-06-04 | Release date: | 2004-02-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc.Natl.Acad.Sci.USA, 101, 2004
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1SK6
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![BU of 1sk6 by Molmil](/molmil-images/mine/1sk6) | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin, ... | Authors: | Guo, Q, Shen, Y, Zhukovskaya, N.L, Tang, W.J. | Deposit date: | 2004-03-04 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate. J.Biol.Chem., 279, 2004
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2J9K
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![BU of 2j9k by Molmil](/molmil-images/mine/2j9k) | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101 | Descriptor: | ACETATE ION, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... | Authors: | Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J. | Deposit date: | 2006-11-11 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors. J.Mol.Biol., 373, 2007
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2J9J
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![BU of 2j9j by Molmil](/molmil-images/mine/2j9j) | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365 | Descriptor: | ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ... | Authors: | Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J. | Deposit date: | 2006-11-11 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors. J.Mol.Biol., 373, 2007
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2JG4
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![BU of 2jg4 by Molmil](/molmil-images/mine/2jg4) | Substrate-free IDE structure in its closed conformation | Descriptor: | 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION | Authors: | Malito, E, Tang, W.J. | Deposit date: | 2007-02-07 | Release date: | 2007-07-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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2JE4
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![BU of 2je4 by Molmil](/molmil-images/mine/2je4) | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365 | Descriptor: | ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ... | Authors: | Malito, E, Johnson, E.C.B, Tang, W.J. | Deposit date: | 2007-01-15 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease. J.Am.Chem.Soc., 129, 2007
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