4RAL
Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta
Replaces: 4QLDSummary for 4RAL
Entry DOI | 10.2210/pdb4ral/pdb |
Descriptor | Insulin-degrading enzyme, C-C motif chemokine 4, ZINC ION, ... (4 entities in total) |
Functional Keywords | ide, mip1alpha, metal-binding, metalloprotease, chemotaxis, inflammatory response, hydrolase-cytokine complex, hydrolase/cytokine |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 Secreted: P13236 |
Total number of polymer chains | 4 |
Total formula weight | 244901.46 |
Authors | Liang, W.G.,Ren, M.,Guo, Q.,Tang, W.J. (deposition date: 2014-09-10, release date: 2015-05-13, Last modification date: 2023-09-20) |
Primary citation | Liang, W.G.,Ren, M.,Zhao, F.,Tang, W.J. Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427:1345-1358, 2015 Cited by PubMed: 25636406DOI: 10.1016/j.jmb.2015.01.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.148 Å) |
Structure validation
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