6BF8

Cryo-EM structure of human insulin degrading enzyme in complex with insulin

Summary for 6BF8

• Entry DOI: 10.2210/pdb6bf8/pdb
• Related: 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7
• EMDB information: 7041 7062 7065 7066 7090 7091 7092
• Descriptor: Insulin-degrading enzyme (1 entity in total)
• Functional Keywords: ide, insulin degrading enzyme, amyloid beta, biosynthetic protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 223732.97

Authors

Liang, W.G.,Zhang, Z.,Bailey, L.J.,Kossiakoff, A.A.,Tan, Y.Z.,Wei, H.,Carragher, B.,Potter, S.C.,Tang, W.J. (deposition date: 2017-10-26, release date: 2018-04-04, Last modification date: 2024-03-13)

• Primary citation: Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.; Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.; Elife, 7:-, 2018; PubMed: 29596046; DOI: 10.7554/eLife.33572

Experimental method

ELECTRON MICROSCOPY (4.2 Å)