7SR9
 
 | | Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | | 著者 | Di Cera, E, Ruben, E.A, Chen, Z. | | 登録日 | 2021-11-08 | | 公開日 | 2021-12-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The active site region plays a critical role in Na + binding to thrombin.
J.Biol.Chem., 298, 2022
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7TPP
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7TPQ
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5JN9
 | | Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide | | 分子名称: | 6-ethoxy-1,3-benzothiazole-2-sulfonamide, ACETATE ION, Carbonic anhydrase 4, ... | | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
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5JN8
 | | Crystal Structure for the complex of human carbonic anhydrase IV and acetazolamide | | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ACETATE ION, Carbonic anhydrase 4, ... | | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
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5JNC
 | | Crystal structure for the complex of human carbonic anhydrase IV and 4-aminomethylbenzene sulfonamide | | 分子名称: | 4-(aminomethyl)benzene-1-sulfonamide, ACETATE ION, Carbonic anhydrase 4, ... | | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
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4H6T
 | | Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A | | 分子名称: | PHOSPHATE ION, Prothrombin | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-09-19 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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4H6S
 | | Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A | | 分子名称: | Prothrombin, SODIUM ION | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-09-19 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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2HWL
 | | Crystal structure of thrombin in complex with fibrinogen gamma' peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen gamma' peptide, Prothrombin, ... | | 著者 | Pineda, A.O, Chen, Z.W, Marino, F, Mathews, F.S, Mosesson, M.W, Di Cera, E. | | 登録日 | 2006-08-01 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of thrombin in complex with fibrinogen gamma' peptide.
Biophys.Chem., 125, 2007
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2HVX
 | | Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design | | 分子名称: | Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID | | 著者 | Greco, M.N, Hawkins, M.J, Powell, E.T, Almond, H.R, de Garavilla, L, Wang, Y, Minor, L.A, Wells, G.I, Di Cera, E, Cantwell, A.M, Savvides, S.N, Damiano, B.P, Maryanoff, B.E. | | 登録日 | 2006-07-31 | | 公開日 | 2007-06-12 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
J.Med.Chem., 50, 2007
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3MVT
 | | Crystal structure of apo mADA at 2.2A resolution | | 分子名称: | Adenosine deaminase, CHLORIDE ION, GLYCEROL | | 著者 | Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. | | 登録日 | 2010-05-04 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
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1SHH
 | | Slow form of Thrombin Bound with PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, thrombin | | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | | 登録日 | 2004-02-25 | | 公開日 | 2004-06-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
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3MVI
 | | Crystal structure of holo mADA at 1.6 A resolution | | 分子名称: | Adenosine deaminase, GLYCEROL, ZINC ION | | 著者 | Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. | | 登録日 | 2010-05-04 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
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1T32
 | | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation | | 分子名称: | 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, Cathepsin G, SULFATE ION | | 著者 | de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E. | | 登録日 | 2004-04-23 | | 公開日 | 2005-03-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
J.Biol.Chem., 280, 2005
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1SFQ
 | | Fast form of thrombin mutant R(77a)A bound to PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, ... | | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | | 登録日 | 2004-02-20 | | 公開日 | 2004-06-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
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4HFP
 | | Structure of thrombin mutant S195a bound to the active site inhibitor argatroban | | 分子名称: | (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, Prothrombin, SODIUM ION | | 著者 | Pozzi, N, Chen, Z, Zapata, F, Lin, W, Barranco-Medina, S, Pelc, L.A, Di Cera, E. | | 登録日 | 2012-10-05 | | 公開日 | 2013-03-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
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6PXQ
 | | Crystal structure of human thrombin mutant D194A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | | 登録日 | 2019-07-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold.
Sci Rep, 9, 2019
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1SGI
 | | Crystal structure of the anticoagulant slow form of thrombin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, thrombin | | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | | 登録日 | 2004-02-23 | | 公開日 | 2004-06-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
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6PX5
 | | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | | 登録日 | 2019-07-24 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
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8FDG
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6PXJ
 | | Crystal structure of human thrombin mutant I16T | | 分子名称: | GLYCEROL, MAGNESIUM ION, Thrombin heavy chain, ... | | 著者 | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | | 登録日 | 2019-07-26 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Role of the I16-D194 ionic interaction in the trypsin fold.
Sci Rep, 9, 2019
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8TN9
 | | Structural architecture of the acidic region of the B domain of coagulation factor V | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor V | | 著者 | Mohammed, B.M, Basore, K, Summers, B, Pelc, L.A, Di Cera, E. | | 登録日 | 2023-08-01 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural architecture of the acidic region of the B domain of coagulation factor V.
J.Thromb.Haemost., 22, 2024
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6P9U
 | | Crystal structure of human thrombin mutant W215A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin, ZINC ION | | 著者 | Pelc, L.A, Koester, S.K, Chen, Z, Di Cera, E. | | 登録日 | 2019-06-10 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
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4HZH
 | | Structure of recombinant Gla-domainless prothrombin mutant S525A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | | 著者 | Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E. | | 登録日 | 2012-11-15 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem., 288, 2013
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4DT7
 | | Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C | | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | | 著者 | Pozzi, N, Barranco-Medina, S, Chen, Z, Di Cera, E. | | 登録日 | 2012-02-20 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Exposure of R169 controls protein C activation and autoactivation.
Blood, 120, 2012
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