4MLF

Crystal structure for the complex of thrombin mutant D102N and hirudin

Summary for 4MLF

Entry DOI	10.2210/pdb4mlf/pdb
Related	1SHH
Descriptor	Thrombin, Hirudin variant-1, SODIUM ION, ... (7 entities in total)
Functional Keywords	serine protease, ligand binding, hirudin, thrombin, conformational selection, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	40965.27
Authors	Vogt, A.D.,Pozzi, N.,Chen, Z.,Di Cera, E. (deposition date: 2013-09-06, release date: 2013-09-25, Last modification date: 2023-09-20)
Primary citation	Vogt, A.D.,Pozzi, N.,Chen, Z.,Di Cera, E. Essential role of conformational selection in ligand binding. Biophys.Chem., 186C:13-21, 2014 Cited by PubMed: 24113284 DOI: 10.1016/j.bpc.2013.09.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation