4MLF
Crystal structure for the complex of thrombin mutant D102N and hirudin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Thrombin | polymer | 33 | 3791.2 | 1 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | |
2 | B | Thrombin | polymer | 259 | 29779.2 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | |
3 | D | Hirudin variant-1 | polymer | 65 | 6973.5 | 1 | UniProt (P01050) Pfam (PF00713) In PDB | Hirudo medicinalis (Medicinal leech) | Hirudin-1, Hirudin-I, Lepirudin |
4 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
6 | B | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
7 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Asn 102 | Asp 462 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 40543.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 421.3 | |
All* | Total formula weight | 40965.3 |