4MLF
Crystal structure for the complex of thrombin mutant D102N and hirudin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombin | polymer | 33 | 3791.2 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (B) | Thrombin | polymer | 259 | 29779.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (D) | Hirudin variant-1 | polymer | 65 | 6973.5 | 1 | UniProt (P01050) Pfam (PF00713) | Hirudo medicinalis (Medicinal leech) | Hirudin-1, Hirudin-I, Lepirudin |
| 4 | D (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F, G, H (B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 7 | I, J, K (A, B, D) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asn 102 | Asp 462 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 40543.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 421.3 | |
| All* | Total formula weight | 40965.3 |
