3HK6
Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)
Summary for 3HK6
| Entry DOI | 10.2210/pdb3hk6/pdb |
| Related | 1TQ0 3HK3 3HKI 3HKJ |
| Descriptor | Thrombin light chain, Thrombin heavy chain (2 entities in total) |
| Functional Keywords | serine protease, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, zymogen |
| Biological source | Mus musculus (mouse) More |
| Total number of polymer chains | 4 |
| Total formula weight | 69802.38 |
| Authors | Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. (deposition date: 2009-05-22, release date: 2009-07-07, Last modification date: 2023-09-06) |
| Primary citation | Gandhi, P.S.,Page, M.J.,Chen, Z.,Bush-Pelc, L.,Di Cera, E. Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A. J.Biol.Chem., 284:24098-24105, 2009 Cited by PubMed: 19586901DOI: 10.1074/jbc.M109.025403 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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