1B7X

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE

Summary for 1B7X

• Entry DOI: 10.2210/pdb1b7x/pdb
• Descriptor: PROTEIN (THROMBIN LIGHT CHAIN), PROTEIN (THROMBIN HEAVY CHAIN), PROTEIN (INHIBITOR), ... (4 entities in total)
• Functional Keywords: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 34246.24

Authors

Caccia, S.,Futterer, K.,Di Cera, E.,Waksman, G. (deposition date: 1999-01-25, release date: 1999-03-02, Last modification date: 2023-08-09)

• Primary citation: Guinto, E.R.,Caccia, S.,Rose, T.,Futterer, K.,Waksman, G.,Di Cera, E.; Unexpected crucial role of residue 225 in serine proteases.; Proc.Natl.Acad.Sci.USA, 96:1852-1857, 1999; PubMed: 10051558; DOI: 10.1073/pnas.96.5.1852

Experimental method

X-RAY DIFFRACTION (2.1 Å)