3BEF

Crystal structure of thrombin bound to the extracellular fragment of PAR1

Summary for 3BEF

Related1SHH 2GP9 3BEI
DescriptorProthrombin, Proteinase-activated receptor 1, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsserine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, secreted, zymogen, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space P00734 P00734
Cell membrane; Multi-pass membrane protein P25116
Total number of polymer chains6
Total molecular weight73193.24
Authors
Gandhi, P.S.,Bah, A.,Chen, Z.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-11-17, release date: 2008-01-01, Last modification date: 2011-07-13)
Primary citation
Gandhi, P.S.,Chen, Z.,Mathews, F.S.,Di Cera, E.
Structural identification of the pathway of long-range communication in an allosteric enzyme.
Proc.Natl.Acad.Sci.Usa, 105:1832-1837, 2008
PubMed: 18250335 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0710894105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249161.4%1.1%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3bef
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Molmil generated image of 3bef
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Molmil generated image of 3bef
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More Biological unit images

Molmil generated image of 3bef
no rotation
Molmil generated image of 3bef
rotated about x axis by 90°
Molmil generated image of 3bef
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3bef.pdb2.gz [54.29 KB])
Coordinate files for Biological unit (3bef.pdb1.gz [55.38 KB])