3BEF
Crystal structure of thrombin bound to the extracellular fragment of PAR1
Summary for 3BEF
Entry DOI | 10.2210/pdb3bef/pdb |
Related | 1SHH 2GP9 3BEI |
Descriptor | Prothrombin, Proteinase-activated receptor 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, secreted, zymogen, g-protein coupled receptor, membrane, phosphoprotein, receptor, transducer, transmembrane |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 73193.24 |
Authors | Gandhi, P.S.,Bah, A.,Chen, Z.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-11-17, release date: 2008-01-01, Last modification date: 2023-08-30) |
Primary citation | Gandhi, P.S.,Chen, Z.,Mathews, F.S.,Di Cera, E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc.Natl.Acad.Sci.Usa, 105:1832-1837, 2008 Cited by PubMed: 18250335DOI: 10.1073/pnas.0710894105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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