3BEF
Crystal structure of thrombin bound to the extracellular fragment of PAR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Prothrombin | polymer | 46 | 5367.9 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | COAGULATION FACTOR II |
| 2 | B, E (B, E) | Prothrombin | polymer | 259 | 29779.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | COAGULATION FACTOR II |
| 3 | C, F (C, F) | Proteinase-activated receptor 1 | polymer | 9 | 1228.3 | 2 | UniProt (P25116) | Homo sapiens (human) | PAR-1, Thrombin receptor, Coagulation factor II receptor |
| 4 | G, H (B, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | I, J, K, L, M... (A, B, C, D, E...) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 15 (UniProt: P00734)
B, E: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Glu 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 102 | Asp 462 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 72750.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 73193.2 |
