3BEF

Crystal structure of thrombin bound to the extracellular fragment of PAR1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Prothrombin	polymer	46	5367.9	2	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)	COAGULATION FACTOR II
2	B, E	Prothrombin	polymer	259	29779.2	2	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)	COAGULATION FACTOR II
3	C, F	Proteinase-activated receptor 1	polymer	9	1228.3	2	UniProt (P25116) In PDB	Homo sapiens (human)	PAR-1, Thrombin receptor, Coagulation factor II receptor
4	B, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	229	Chemie (HOH)

Sequence modifications

A, D: 1 - 15 (UniProt: P00734)

PDB	External Database	Details
Ser 1	-	expression tag
Glu 1	-	expression tag

B, E: 16 - 247 (UniProt: P00734)

PDB	External Database	Details
Asn 102	Asp 462	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	72750.8
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	73193.2

*Water molecules are not included.