3BEI

Crystal structure of the slow form of thrombin in a self_inhibited conformation

Summary for 3BEI

• Entry DOI: 10.2210/pdb3bei/pdb
• Related: 2GP9 3BEF
• Descriptor: Prothrombin, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (5 entities in total)
• Functional Keywords: serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, secreted, zymogen
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35336.33

Authors

Gandhi, P.S.,Chen, Z.,Mathews, F.S.,Di Cera, E. (deposition date: 2007-11-19, release date: 2007-12-25, Last modification date: 2023-08-30)

• Primary citation: Gandhi, P.S.,Chen, Z.,Mathews, F.S.,Di Cera, E.; Structural identification of the pathway of long-range communication in an allosteric enzyme.; Proc.Natl.Acad.Sci.Usa, 105:1832-1837, 2008; PubMed: 18250335; DOI: 10.1073/pnas.0710894105

Experimental method

X-RAY DIFFRACTION (1.55 Å)