5KU6

Crystal structure for the complex of human carbonic anhydrase IV and methazolamide

Summary for 5KU6

Entry DOI	10.2210/pdb5ku6/pdb
Related	1ZNC
Descriptor	Carbonic anhydrase 4, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION, ... (7 entities in total)
Functional Keywords	carbonic anhydrase, intrinsic thermodynamics, lyase, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	124070.72
Authors	Chen, Z.,Waheed, A.,Di Cera, E.,Sly, W.S. (deposition date: 2016-07-12, release date: 2017-07-26, Last modification date: 2023-10-04)
Primary citation	Mickeviciute, A.,Timm, D.D.,Gedgaudas, M.,Linkuviene, V.,Chen, Z.,Waheed, A.,Michailoviene, V.,Zubriene, A.,Smirnov, A.,Capkauskaite, E.,Baranauskiene, L.,Jachno, J.,Revuckiene, J.,Manakova, E.,Grazulis, S.,Matuliene, J.,Di Cera, E.,Sly, W.S.,Matulis, D. Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. Eur. Biophys. J., 47:271-290, 2018 Cited by PubMed: 28975383 DOI: 10.1007/s00249-017-1256-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation