3JZ1

Crystal structure of human thrombin mutant N143P in E:Na+ form

Summary for 3JZ1

• Entry DOI: 10.2210/pdb3jz1/pdb
• Related: 1SHH 3BEI 3JZ2
• Descriptor: Thrombin light chain, Thrombin heavy chain, SODIUM ION, ... (7 entities in total)
• Functional Keywords: serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 34343.06

Authors

Niu, W.,Chen, Z.,Bush-Pelc, L.A.,Bah, A.,Gandhi, P.S.,Di Cera, E. (deposition date: 2009-09-22, release date: 2009-10-20, Last modification date: 2023-09-06)

• Primary citation: Niu, W.,Chen, Z.,Bush-Pelc, L.A.,Bah, A.,Gandhi, P.S.,Di Cera, E.; Mutant N143P reveals how Na+ activates thrombin; J.Biol.Chem., 284:36175-36185, 2009; PubMed: 19846563; DOI: 10.1074/jbc.M109.069500

Experimental method

X-RAY DIFFRACTION (1.6 Å)