3JZ2
Crystal structure of human thrombin mutant N143P in E* form
Summary for 3JZ2
Entry DOI | 10.2210/pdb3jz2/pdb |
Related | 1SHH 3BEI 3JZ1 |
Descriptor | Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | serine protease, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 34449.35 |
Authors | Niu, W.,Chen, Z.,Bush-Pelc, L.A.,Bah, A.,Gandhi, P.S.,Di Cera, E. (deposition date: 2009-09-22, release date: 2009-10-20, Last modification date: 2023-09-06) |
Primary citation | Niu, W.,Chen, Z.,Bush-Pelc, L.A.,Bah, A.,Gandhi, P.S.,Di Cera, E. Mutant N143P reveals how Na+ activates thrombin J.Biol.Chem., 284:36175-36185, 2009 Cited by PubMed: 19846563DOI: 10.1074/jbc.M109.069500 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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