7SR9

Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C

Summary for 7SR9

• Entry DOI: 10.2210/pdb7sr9/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, SULFATE ION, ... (6 entities in total)
• Functional Keywords: thrombin, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 33847.58

Authors

Di Cera, E.,Ruben, E.A.,Chen, Z. (deposition date: 2021-11-08, release date: 2021-12-08, Last modification date: 2023-10-18)

• Primary citation: Pelc, L.A.,Koester, S.K.,Kukla, C.R.,Chen, Z.,Di Cera, E.; The active site region plays a critical role in Na + binding to thrombin.; J.Biol.Chem., 298:101458-101458, 2022; PubMed: 34861239; DOI: 10.1016/j.jbc.2021.101458

Experimental method

X-RAY DIFFRACTION (2.1 Å)