7SR9
Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thrombin light chain | polymer | 35 | 3995.4 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | |
| 2 | B (B) | Thrombin heavy chain | polymer | 253 | 29058.5 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | |
| 3 | C, E, F, G, H (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
B: 16 - 244 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ile 184 | Tyr 553 | engineered mutation |
| Leu 184 | Lys 554 | engineered mutation |
| - | Pro 555 | deletion |
| - | Asp 556 | deletion |
| - | Glu 557 | deletion |
| Asp 186 | Lys 559 | engineered mutation |
| Gln 188 | Gly 561 | engineered mutation |
| Gly 221 | Asp 595 | engineered mutation |
| Leu 221 | Arg 596 | engineered mutation |
| Leu 222 | Asp 597 | engineered mutation |
| His 223 | Gly 598 | engineered mutation |
| Asn 224 | Lys 599 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33054.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 793.6 | |
| All* | Total formula weight | 33847.6 |
