8TN9
Structural architecture of the acidic region of the B domain of coagulation factor V
Summary for 8TN9
| Entry DOI | 10.2210/pdb8tn9/pdb |
| EMDB information | 41411 |
| Descriptor | Coagulation factor V, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total) |
| Functional Keywords | coagulation, pro-cofactor, factor v, b domain, acidic region, blood clotting |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 249858.07 |
| Authors | Mohammed, B.M.,Basore, K.,Summers, B.,Pelc, L.A.,Di Cera, E. (deposition date: 2023-08-01, release date: 2023-10-04, Last modification date: 2024-11-20) |
| Primary citation | Mohammed, B.M.,Basore, K.,Summers, B.,Pelc, L.A.,Di Cera, E. Structural architecture of the acidic region of the B domain of coagulation factor V. J.Thromb.Haemost., 22:709-714, 2024 Cited by PubMed Abstract: Coagulation factor (F)V features an A1-A2-B-A3-C1-C2 domain organization and functions as the inactive precursor of FVa, a component of the prothrombinase complex required for rapid thrombin generation in the penultimate step of the coagulation cascade. An intramolecular interaction within the large B domain (residues 710-1545) involves the basic region (BR, residues 963-1008) and acidic region (AR, residues 1493-1537) and locks FV in its inactive state. However, structural information on this important regulatory interaction or on the separate architecture of the AR and BR remains elusive due to conformational disorder of the B domain. PubMed: 38007061DOI: 10.1016/j.jtha.2023.11.003 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.05 Å) |
Structure validation
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