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PDB: 189 件
4GS8
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Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid
分子名称: Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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BU of 4gsc by Molmil
Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
5C79
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PH domain of ASAP1 in complex with diC4-PtdIns(4,5)P2
分子名称: (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, Arf-GAP, CHLORIDE ION
著者Xia, D, Tang, W.K.
登録日2015-06-24
公開日2015-10-07
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.
Structure, 23, 2015
4RA8
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BU of 4ra8 by Molmil
Structure analysis of the Mip1a P8A mutant
分子名称: C-C motif chemokine 3
著者Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
登録日2014-09-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RAL
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BU of 4ral by Molmil
Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta
分子名称: C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION
著者Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
登録日2014-09-10
公開日2015-05-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.148 Å)
主引用文献Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4QIA
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BU of 4qia by Molmil
Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine
分子名称: Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2014-05-30
公開日2015-05-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
8H0J
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Annexin A5 mutant
分子名称: Annexin A5, CALCIUM ION
著者Hua, Z.C, Tang, W.
登録日2022-09-29
公開日2023-10-04
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
8GYC
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Annexin A5 protein dimer mutant
分子名称: Annexin A5, CALCIUM ION
著者Hua, Z.C, Tang, W.
登録日2022-09-22
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation
To Be Published
4M1C
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Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
分子名称: Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ...
著者McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J.
登録日2013-08-02
公開日2014-08-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5007 Å)
主引用文献Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
To be Published
2J9K
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Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101
分子名称: ACETATE ION, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ...
著者Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J.
登録日2006-11-11
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.
J.Mol.Biol., 373, 2007
2J9J
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Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365
分子名称: ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ...
著者Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J.
登録日2006-11-11
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.04 Å)
主引用文献Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.
J.Mol.Biol., 373, 2007
2JBU
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BU of 2jbu by Molmil
Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.
分子名称: 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME
著者Im, H, Shen, Y, Tang, W.J.
登録日2006-12-11
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2JE4
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Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365
分子名称: ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ...
著者Malito, E, Johnson, E.C.B, Tang, W.J.
登録日2007-01-15
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease.
J.Am.Chem.Soc., 129, 2007
2JG4
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Substrate-free IDE structure in its closed conformation
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION
著者Malito, E, Tang, W.J.
登録日2007-02-07
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
6IXN
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BU of 6ixn by Molmil
Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and citrate
分子名称: CITRATE ANION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Zhu, G.P, Tang, W.G, Wang, P.
登録日2018-12-11
公開日2019-12-18
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021
1K93
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BU of 1k93 by Molmil
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
分子名称: CALCIUM ION, CALMODULIN, CALMODULIN-SENSITIVE ADENYLATE CYCLASE, ...
著者Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J.
登録日2001-10-26
公開日2002-01-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature, 415, 2002
1I5T
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SOLUTION STRUCTURE OF CYANOFERRICYTOCHROME C
分子名称: CYANIDE ION, CYTOCHROME C, HEME C
著者Yao, Y, Qian, C, Ye, K, Wang, J, Tang, W.
登録日2001-02-28
公開日2001-03-21
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution structure of cyanoferricytochrome c: ligand-controlled conformational flexibility and electronic structure of the heme moiety.
J.Biol.Inorg.Chem., 7, 2002
6IXT
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BU of 6ixt by Molmil
Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and Mg2+
分子名称: GLYCEROL, Isocitrate dehydrogenase, MAGNESIUM ION, ...
著者Zhu, G.P, Tang, W.G, Wang, P.
登録日2018-12-12
公開日2019-12-18
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021
1M60
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BU of 1m60 by Molmil
Solution Structure of Zinc-substituted cytochrome c
分子名称: ZINC SUBSTITUTED HEME C, Zinc-substituted cytochrome c
著者Qian, C, Yao, Y, Tong, Y, Wang, J, Tang, W.
登録日2002-07-11
公開日2002-08-07
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Structural analysis of zinc-substituted cytochrome c.
J.Biol.Inorg.Chem., 8, 2003
1NMI
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BU of 1nmi by Molmil
Solution structure of the imidazole complex of iso-1 cytochrome c
分子名称: Cytochrome c, iso-1, HEME C, ...
著者Yao, Y, Tong, Y, Liu, G, Wang, J, Zheng, J, Tang, W.
登録日2003-01-10
公開日2003-02-04
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution structure of the imidazole complex of iso-1 cytochrome c
To be Published
4KLN
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Structure of p97 N-D1 A232E mutant in complex with ATPgS
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
著者Xia, D, Tang, W.K.
登録日2013-05-07
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
4KOD
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Structure of p97 N-D1 R155H mutant in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
著者Xia, D, Tang, W.K.
登録日2013-05-11
公開日2013-11-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J.Biol.Chem., 288, 2013
8J23
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Cryo-EM structure of FFAR2 complex in apo state
分子名称: Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Tai, L, Li, F, Sun, X, Tang, W, Wang, J.
登録日2023-04-14
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular recognition and activation mechanism of short chain fatty acid receptors FFAR2 and FFAR3
To Be Published
3QZ2
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The structure of cysteine-free human insulin degrading enzyme
分子名称: Insulin-degrading enzyme, ZINC ION
著者Guo, Q, Tang, W.J.
登録日2011-03-04
公開日2012-01-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
6IXL
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BU of 6ixl by Molmil
Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri
分子名称: GLYCEROL, Isocitrate dehydrogenase, SULFATE ION
著者Zhu, G.P, Tang, W.G, Wang, P.
登録日2018-12-11
公開日2019-12-18
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021

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