7JUM
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4NGE
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![BU of 4nge by Molmil](/molmil-images/mine/4nge) | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | 分子名称: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | 著者 | King, J.V, Liang, W.G, Tang, W.J. | 登録日 | 2013-11-01 | 公開日 | 2014-05-14 | 最終更新日 | 2014-07-23 | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | 主引用文献 | Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22, 2014
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6C6D
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4M1C
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![BU of 4m1c by Molmil](/molmil-images/mine/4m1c) | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) | 分子名称: | Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ... | 著者 | McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J. | 登録日 | 2013-08-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5007 Å) | 主引用文献 | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) To be Published
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1K93
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![BU of 1k93 by Molmil](/molmil-images/mine/1k93) | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin | 分子名称: | CALCIUM ION, CALMODULIN, CALMODULIN-SENSITIVE ADENYLATE CYCLASE, ... | 著者 | Drum, C.L, Yan, S.-Z, Bard, J, Shen, Y.-Q, Lu, D, Soelaiman, S, Grabarek, Z, Bohm, A, Tang, W.-J. | 登録日 | 2001-10-26 | 公開日 | 2002-01-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature, 415, 2002
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7U9J
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![BU of 7u9j by Molmil](/molmil-images/mine/7u9j) | Crystal structure of Mesothelin-207 fragment | 分子名称: | GLYCEROL, Isoform 3 of Mesothelin, SULFATE ION | 著者 | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | 登録日 | 2022-03-10 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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1I5T
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![BU of 1i5t by Molmil](/molmil-images/mine/1i5t) | SOLUTION STRUCTURE OF CYANOFERRICYTOCHROME C | 分子名称: | CYANIDE ION, CYTOCHROME C, HEME C | 著者 | Yao, Y, Qian, C, Ye, K, Wang, J, Tang, W. | 登録日 | 2001-02-28 | 公開日 | 2001-03-21 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of cyanoferricytochrome c: ligand-controlled conformational flexibility and electronic structure of the heme moiety. J.Biol.Inorg.Chem., 7, 2002
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7UED
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![BU of 7ued by Molmil](/molmil-images/mine/7ued) | Crystal structure of full length mesothelin bound with MORAb-009 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Isoform 4 of Mesothelin, ... | 著者 | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | 登録日 | 2022-03-21 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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1M60
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![BU of 1m60 by Molmil](/molmil-images/mine/1m60) | Solution Structure of Zinc-substituted cytochrome c | 分子名称: | ZINC SUBSTITUTED HEME C, Zinc-substituted cytochrome c | 著者 | Qian, C, Yao, Y, Tong, Y, Wang, J, Tang, W. | 登録日 | 2002-07-11 | 公開日 | 2002-08-07 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural analysis of zinc-substituted cytochrome c. J.Biol.Inorg.Chem., 8, 2003
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2J9K
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![BU of 2j9k by Molmil](/molmil-images/mine/2j9k) | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor MVT-101 | 分子名称: | ACETATE ION, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... | 著者 | Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J. | 登録日 | 2006-11-11 | 公開日 | 2007-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors. J.Mol.Biol., 373, 2007
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2J9J
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![BU of 2j9j by Molmil](/molmil-images/mine/2j9j) | Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365 | 分子名称: | ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ... | 著者 | Malito, E, Shen, Y, Johnson, E.C.B, Tang, W.J. | 登録日 | 2006-11-11 | 公開日 | 2007-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors. J.Mol.Biol., 373, 2007
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2JG4
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![BU of 2jg4 by Molmil](/molmil-images/mine/2jg4) | Substrate-free IDE structure in its closed conformation | 分子名称: | 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION | 著者 | Malito, E, Tang, W.J. | 登録日 | 2007-02-07 | 公開日 | 2007-07-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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2JE4
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![BU of 2je4 by Molmil](/molmil-images/mine/2je4) | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365 | 分子名称: | ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ... | 著者 | Malito, E, Johnson, E.C.B, Tang, W.J. | 登録日 | 2007-01-15 | 公開日 | 2007-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease. J.Am.Chem.Soc., 129, 2007
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4KO8
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![BU of 4ko8 by Molmil](/molmil-images/mine/4ko8) | Structure of p97 N-D1 R155H mutant in complex with ATPgS | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | 著者 | Xia, D, Tang, W.K. | 登録日 | 2013-05-11 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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2JBU
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![BU of 2jbu by Molmil](/molmil-images/mine/2jbu) | Crystal structure of human insulin degrading enzyme complexed with co- purified peptides. | 分子名称: | 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME | 著者 | Im, H, Shen, Y, Tang, W.J. | 登録日 | 2006-12-11 | 公開日 | 2007-07-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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8GJM
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![BU of 8gjm by Molmil](/molmil-images/mine/8gjm) | 17b10 fab in complex with full-length SARS-CoV-2 Spike G614 trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kwon, H.J, Zhang, J, Kosikova, M, Tang, W.C, Rodriguez, U.O, Peng, H.Q, Meseda, C.A, Pedro, C.L, Schmeisser, F, Lu, J.M, Zhou, B, Davis, C.T, Wentworth, D.E, Chen, W.H, Shriver, M.C, Pasetti, M.F, Weir, J.P, Chen, B, Xie, H. | 登録日 | 2023-03-16 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS-CoV-2. J Med Virol, 95, 2023
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3QZ2
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4F33
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![BU of 4f33 by Molmil](/molmil-images/mine/4f33) | Crystal Structure of therapeutic antibody MORAb-009 | 分子名称: | MORAb-009 FAB heavy chain, MORAb-009 FAB light chain, TETRAETHYLENE GLYCOL | 著者 | Xia, D, Ma, J, Tang, W.K, Esser, L. | 登録日 | 2012-05-08 | 公開日 | 2012-07-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J.Biol.Chem., 287, 2012
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2PQ3
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8GJN
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![BU of 8gjn by Molmil](/molmil-images/mine/8gjn) | 17B10 fab in complex with up-RBD of SARS-CoV-2 Spike G614 trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 17B10 Fab, Light chain of 17B10 Fab, ... | 著者 | Kwon, H.J, Zhang, J, Kosikova, M, Tang, W.C, Rodriguez, U.O, Peng, H.Q, Meseda, C.A, Pedro, C.L, Schmeisser, F, Lu, J.M, Zhou, B, Davis, C.T, Wentworth, D.E, Chen, W.H, Shriver, M.C, Pasetti, M.F, Weir, J.P, Chen, B, Xie, H. | 登録日 | 2023-03-16 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS-CoV-2. J Med Virol, 95, 2023
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4DWK
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![BU of 4dwk by Molmil](/molmil-images/mine/4dwk) | Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | 分子名称: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate | 著者 | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | 登録日 | 2012-02-24 | 公開日 | 2013-04-03 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4F3F
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![BU of 4f3f by Molmil](/molmil-images/mine/4f3f) | Crystal Structure of Msln7-64 MORAb-009 FAB complex | 分子名称: | MORAb-009 Fab heavy chain, MORAb-009 Fab light chain, Mesothelin | 著者 | Xia, D, Pastan, I, Ma, J, Tang, W.K, Esser, L. | 登録日 | 2012-05-09 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J.Biol.Chem., 287, 2012
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4DTT
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![BU of 4dtt by Molmil](/molmil-images/mine/4dtt) | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | 分子名称: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION | 著者 | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | 登録日 | 2012-02-21 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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7K1V
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8GYC
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![BU of 8gyc by Molmil](/molmil-images/mine/8gyc) | Annexin A5 protein dimer mutant | 分子名称: | Annexin A5, CALCIUM ION | 著者 | Hua, Z.C, Tang, W. | 登録日 | 2022-09-22 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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