4NGE
Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)
Summary for 4NGE
Entry DOI | 10.2210/pdb4nge/pdb |
Related | 4L3T |
Descriptor | Presequence protease, mitochondrial, Beta-amyloid protein 40, ZINC ION, ... (8 entities in total) |
Functional Keywords | m16 metalloprotease, alzheimer's disease, zinc metalloendoprotease, monomethyllysine, dimethyllysine, s-(dimethylarsenic)cysteine, mitochondrial matrix, hydrolase-protein binding complex, hydrolase/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion matrix: Q5JRX3 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 6 |
Total formula weight | 241758.94 |
Authors | King, J.V.,Liang, W.G.,Tang, W.J. (deposition date: 2013-11-01, release date: 2014-05-14, Last modification date: 2014-07-23) |
Primary citation | King, J.V.,Liang, W.G.,Scherpelz, K.P.,Schilling, A.B.,Meredith, S.C.,Tang, W.J. Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22:996-1007, 2014 Cited by PubMed: 24931469DOI: 10.1016/j.str.2014.05.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.704 Å) |
Structure validation
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