4NGE
Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Presequence protease, mitochondrial | polymer | 1014 | 115762.1 | 1 | UniProt (Q5JRX3) Pfam (PF00675) Pfam (PF05193) Pfam (PF08367) Pfam (PF22516) | Homo sapiens (human) | hPreP, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1 |
| 2 | B, E (B, E) | Beta-amyloid protein 40 | polymer | 40 | 4335.9 | 2 | UniProt (P05067) Pfam (PF03494) | Homo sapiens | Beta-APP40 |
| 3 | C, F (C, F) | Beta-amyloid protein 40 | polymer | 7 | 613.7 | 2 | Homo sapiens (human) | hPreP, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1 | |
| 4 | D (D) | Presequence protease, mitochondrial | polymer | 1014 | 115572.4 | 1 | UniProt (Q5JRX3) Pfam (PF00675) Pfam (PF05193) Pfam (PF08367) Pfam (PF22516) | Homo sapiens | Beta-APP40 |
| 5 | G, M (A, E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | H, K, L (A, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | I, J (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 8 | N, O, P (A, D, E) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 33 - 1037 (UniProt: Q5JRX3)
D: 33 - 1037 (UniProt: Q5JRX3)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| His 29 | - | expression tag |
| His 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Gln 107 | Glu 107 | engineered mutation |
| Val 328 | Ile 328 | SEE REMARK 999 |
| Val 397 | Ala 397 | SEE REMARK 999 |
| Arg 1037 | Gln 1037 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| His 29 | - | expression tag |
| His 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Gln 107 | Glu 107 | engineered mutation |
| Val 328 | Ile 328 | SEE REMARK 999 |
| Val 397 | Ala 397 | SEE REMARK 999 |
| Arg 1037 | Gln 1037 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 241233.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 525.2 | |
| All* | Total formula weight | 241758.9 |
