4V8Y
 
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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6GX5
 | | Narrow Pick Filament from Pick's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-06-26 | | Release date: | 2018-09-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
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5A63
 | | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | | Deposit date: | 2015-06-24 | | Release date: | 2015-08-05 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
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7R5H
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7R4T
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6ZOZ
 | | Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Locked State | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | | Deposit date: | 2020-07-08 | | Release date: | 2020-07-22 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
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6VPS
 | | Cryo-EM structure of the amyloid core of Drosophila Orb2 isolated from head | | Descriptor: | Translational regulator orb2 | | Authors: | Hervas, R, Rau, M.J, Park, Y, Zhang, W, Murzin, A.G, Fitzpatrick, J.A.J, Scheres, S.H.W, Si, K. | | Deposit date: | 2020-02-04 | | Release date: | 2020-03-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila
Science, 367, 2020
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3J9L
 | | Structure of Dark apoptosome from Drosophila melanogaster | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apaf-1 related killer DARK | | Authors: | Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y. | | Deposit date: | 2015-02-04 | | Release date: | 2015-02-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29, 2015
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4V92
 | | Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | | Descriptor: | 18S RRNA, ES1, ES10, ... | | Authors: | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | | Deposit date: | 2014-03-21 | | Release date: | 2014-07-09 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
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4V91
 | | Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES | | Descriptor: | 25S RRNA, 5.8S RRNA, 5S RRNA, ... | | Authors: | Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V. | | Deposit date: | 2014-03-21 | | Release date: | 2014-07-09 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
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6HRE
 | | Paired helical filament from sporadic Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-09-26 | | Release date: | 2018-10-10 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
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6HRF
 | | Straight filament from sporadic Alzheimer's disease brain | | Descriptor: | Microtubule-associated protein tau | | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2018-09-26 | | Release date: | 2018-10-10 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
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5FKU
 | | cryo-EM structure of the E. coli replicative DNA polymerase complex in DNA free state (DNA polymerase III alpha, beta, epsilon, tau complex) | | Descriptor: | DNA POLYMERASE III SUBUNIT ALPHA, DNA POLYMERASE III SUBUNIT BETA, DNA POLYMERASE III SUBUNIT EPSILON, ... | | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | | Deposit date: | 2015-10-20 | | Release date: | 2015-11-25 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.34 Å) | | Cite: | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau.
Elife, 4, 2015
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4V8Z
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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4V5X
 | | The cryo-EM structure of a 3D DNA-origami object | | Descriptor: | SCAFFOLD STRAND,SCAFFOLD STRAND, STAPLE STRAND | | Authors: | Bai, X.C, Martin, T.G, Scheres, S.H.W, Dietz, H. | | Deposit date: | 2012-10-09 | | Release date: | 2014-07-09 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (11.5 Å) | | Cite: | Cryo-Em Structure of a 3D DNA-Origami Object.
Proc.Natl.Acad.Sci.USA, 109, 2012
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5M1S
 | | Cryo-EM structure of the E. coli replicative DNA polymerase-clamp-exonuclase-theta complex bound to DNA in the editing mode | | Descriptor: | DNA Primer Strand, DNA Template Strand, DNA polymerase III subunit alpha, ... | | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | | Deposit date: | 2016-10-10 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6.7 Å) | | Cite: | Self-correcting mismatches during high-fidelity DNA replication.
Nat. Struct. Mol. Biol., 24, 2017
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6XYP
 | | Multiple system atrophy Type II-1 alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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6XYQ
 | | Multiple system atrophy Type II-2 alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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6XYO
 | | Multiple system atrophy Type I alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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6OKK
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6SRI
 | | Structure of the Fanconi anaemia core complex | | Descriptor: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (base region, proposed FANCC-FANC-E-FANCF), ... | | Authors: | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | | Deposit date: | 2019-09-05 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
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6TJO
 | | Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration | | Descriptor: | Microtubule-associated protein tau | | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2019-11-26 | | Release date: | 2020-02-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
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6SRS
 | | Structure of the Fanconi anaemia core subcomplex | | Descriptor: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (central region, proposed FANCB-FAAP100), ... | | Authors: | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | | Deposit date: | 2019-09-05 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
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6TJX
 | | Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration | | Descriptor: | Microtubule-associated protein tau | | Authors: | Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. | | Deposit date: | 2019-11-27 | | Release date: | 2020-02-05 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Novel tau filament fold in corticobasal degeneration.
Nature, 580, 2020
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5GAM
 | | Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ... | | Authors: | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | | Deposit date: | 2015-12-15 | | Release date: | 2016-02-03 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
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