6HRE

Paired helical filament from sporadic Alzheimer's disease brain

Summary for 6HRE

• Entry DOI: 10.2210/pdb6hre/pdb
• Related: 5O3L
• EMDB information: 0259 3741
• Descriptor: Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: tau, helical, filament, fibril, amyloid, alzheimer's disease, phf, paired helical filament, nft, neurofibrillary tangly, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 275519.23

Authors

Falcon, B.,Zhang, W.,Schweighauser, M.,Murzin, A.G.,Vidal, R.,Garringer, H.J.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. (deposition date: 2018-09-26, release date: 2018-10-10, Last modification date: 2022-03-30)

• Primary citation: Falcon, B.,Zhang, W.,Schweighauser, M.,Murzin, A.G.,Vidal, R.,Garringer, H.J.,Ghetti, B.,Scheres, S.H.W.,Goedert, M.; Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.; Acta Neuropathol., 136:699-708, 2018; PubMed: 30276465; DOI: 10.1007/s00401-018-1914-z

Experimental method

ELECTRON MICROSCOPY (3.2 Å)