3J9L

Structure of Dark apoptosome from Drosophila melanogaster

This is a large structure.

> Summary

Summary for 3J9L

Related3J9K
EMDB informationEMD-2871 EMD-2870
DescriptorApaf-1 related killer DARK, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE (2 entities in total)
Functional Keywordsprogrammed cell death, apoptosis
Biological sourceDrosophila melanogaster (Fruit fly)
Total number of polymer chains16
Total molecular weight1812728.26
Authors
Pang, Y.,Bai, X.,Yan, C.,Hao, Q.,Chen, Z.,Wang, J.,Scheres, S.H.W.,Shi, Y. (deposition date: 2015-02-04, release date: 2015-02-25)
Primary citation
Pang, Y.,Bai, X.C.,Yan, C.,Hao, Q.,Chen, Z.,Wang, J.W.,Scheres, S.H.,Shi, Y.
Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Genes Dev., 29:277-287, 2015
PubMed: 25644603 (PDB entries with the same primary citation)
DOI: 10.1101/gad.255877.114
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers810.9%26.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j9l
no rotation
Molmil generated image of 3j9l
rotated about x axis by 90°
Molmil generated image of 3j9l
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
A, C, D, E, F...Apaf-1 related killer DARKpolymer1103112835.016
UniProt (Q7KLI1)
Pfam (PF00931)
Drosophila melanogaster (Fruit fly)@PDBjApaf-1-related-killer, isoform B, Apaf-1/CED-4-related caspase activator Dapaf-1L, Cell death protein HAC-1, FI21208p1
2'-DEOXYADENOSINE 5'-TRIPHOSPHATEnon-polymer491.215

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains16
Total molecular weight1805360.5
Non-Polymers*Number of molecules15
Total molecular weight7367.8
All*Total molecular weight1812728.3
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:ELECTRON MICROSCOPY

Cell axes1.0001.0001.000
Cell angles90.0090.0090.00
SpacegroupP 1
Resolution limits -
the highest resolution shell value -

Data Collection Statistics

Resolution limits -
the highest resolution shell value -

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*

> Functional details

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0043293cellular_componentapoptosome
A0043531molecular_functionADP binding
A0005524molecular_functionATP binding
A0050700molecular_functionCARD domain binding
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
A0006915biological_processapoptotic process
A0097190biological_processapoptotic signaling pathway
A0021556biological_processcentral nervous system formation
A0048813biological_processdendrite morphogenesis
A0035006biological_processmelanization defense response
A0002921biological_processnegative regulation of humoral immune response
A0070050biological_processneuron cellular homeostasis
A0043065biological_processpositive regulation of apoptotic process
A0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
A0034352biological_processpositive regulation of glial cell apoptotic process
A0012501biological_processprogrammed cell death
A0051291biological_processprotein heterooligomerization
A0051260biological_processprotein homooligomerization
A0046668biological_processregulation of retinal cell programmed cell death
A0010332biological_processresponse to gamma radiation
A0042594biological_processresponse to starvation
A0033353biological_processS-adenosylmethionine cycle
A0035071biological_processsalivary gland cell autophagic cell death
A0035070biological_processsalivary gland histolysis
A1901053biological_processsarcosine catabolic process
A0007423biological_processsensory organ development
A0007291biological_processsperm individualization
A0070328biological_processtriglyceride homeostasis
C0043293cellular_componentapoptosome
C0043531molecular_functionADP binding
C0005524molecular_functionATP binding
C0050700molecular_functionCARD domain binding
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
C0006915biological_processapoptotic process
C0097190biological_processapoptotic signaling pathway
C0021556biological_processcentral nervous system formation
C0048813biological_processdendrite morphogenesis
C0035006biological_processmelanization defense response
C0002921biological_processnegative regulation of humoral immune response
C0070050biological_processneuron cellular homeostasis
C0043065biological_processpositive regulation of apoptotic process
C0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
C0034352biological_processpositive regulation of glial cell apoptotic process
C0012501biological_processprogrammed cell death
C0051291biological_processprotein heterooligomerization
C0051260biological_processprotein homooligomerization
C0046668biological_processregulation of retinal cell programmed cell death
C0010332biological_processresponse to gamma radiation
C0042594biological_processresponse to starvation
C0033353biological_processS-adenosylmethionine cycle
C0035071biological_processsalivary gland cell autophagic cell death
C0035070biological_processsalivary gland histolysis
C1901053biological_processsarcosine catabolic process
C0007423biological_processsensory organ development
C0007291biological_processsperm individualization
C0070328biological_processtriglyceride homeostasis
D0043293cellular_componentapoptosome
D0043531molecular_functionADP binding
D0005524molecular_functionATP binding
D0050700molecular_functionCARD domain binding
D0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
D0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
D0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
D0006915biological_processapoptotic process
D0097190biological_processapoptotic signaling pathway
D0021556biological_processcentral nervous system formation
D0048813biological_processdendrite morphogenesis
D0035006biological_processmelanization defense response
D0002921biological_processnegative regulation of humoral immune response
D0070050biological_processneuron cellular homeostasis
D0043065biological_processpositive regulation of apoptotic process
D0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
D0034352biological_processpositive regulation of glial cell apoptotic process
D0012501biological_processprogrammed cell death
D0051291biological_processprotein heterooligomerization
D0051260biological_processprotein homooligomerization
D0046668biological_processregulation of retinal cell programmed cell death
D0010332biological_processresponse to gamma radiation
D0042594biological_processresponse to starvation
D0033353biological_processS-adenosylmethionine cycle
D0035071biological_processsalivary gland cell autophagic cell death
D0035070biological_processsalivary gland histolysis
D1901053biological_processsarcosine catabolic process
D0007423biological_processsensory organ development
D0007291biological_processsperm individualization
D0070328biological_processtriglyceride homeostasis
E0043293cellular_componentapoptosome
E0043531molecular_functionADP binding
E0005524molecular_functionATP binding
E0050700molecular_functionCARD domain binding
E0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
E0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
E0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
E0006915biological_processapoptotic process
E0097190biological_processapoptotic signaling pathway
E0021556biological_processcentral nervous system formation
E0048813biological_processdendrite morphogenesis
E0035006biological_processmelanization defense response
E0002921biological_processnegative regulation of humoral immune response
E0070050biological_processneuron cellular homeostasis
E0043065biological_processpositive regulation of apoptotic process
E0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
E0034352biological_processpositive regulation of glial cell apoptotic process
E0012501biological_processprogrammed cell death
E0051291biological_processprotein heterooligomerization
E0051260biological_processprotein homooligomerization
E0046668biological_processregulation of retinal cell programmed cell death
E0010332biological_processresponse to gamma radiation
E0042594biological_processresponse to starvation
E0033353biological_processS-adenosylmethionine cycle
E0035071biological_processsalivary gland cell autophagic cell death
E0035070biological_processsalivary gland histolysis
E1901053biological_processsarcosine catabolic process
E0007423biological_processsensory organ development
E0007291biological_processsperm individualization
E0070328biological_processtriglyceride homeostasis
F0043293cellular_componentapoptosome
F0043531molecular_functionADP binding
F0005524molecular_functionATP binding
F0050700molecular_functionCARD domain binding
F0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
F0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
F0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
F0006915biological_processapoptotic process
F0097190biological_processapoptotic signaling pathway
F0021556biological_processcentral nervous system formation
F0048813biological_processdendrite morphogenesis
F0035006biological_processmelanization defense response
F0002921biological_processnegative regulation of humoral immune response
F0070050biological_processneuron cellular homeostasis
F0043065biological_processpositive regulation of apoptotic process
F0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
F0034352biological_processpositive regulation of glial cell apoptotic process
F0012501biological_processprogrammed cell death
F0051291biological_processprotein heterooligomerization
F0051260biological_processprotein homooligomerization
F0046668biological_processregulation of retinal cell programmed cell death
F0010332biological_processresponse to gamma radiation
F0042594biological_processresponse to starvation
F0033353biological_processS-adenosylmethionine cycle
F0035071biological_processsalivary gland cell autophagic cell death
F0035070biological_processsalivary gland histolysis
F1901053biological_processsarcosine catabolic process
F0007423biological_processsensory organ development
F0007291biological_processsperm individualization
F0070328biological_processtriglyceride homeostasis
G0043293cellular_componentapoptosome
G0043531molecular_functionADP binding
G0005524molecular_functionATP binding
G0050700molecular_functionCARD domain binding
G0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
G0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
G0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
G0006915biological_processapoptotic process
G0097190biological_processapoptotic signaling pathway
G0021556biological_processcentral nervous system formation
G0048813biological_processdendrite morphogenesis
G0035006biological_processmelanization defense response
G0002921biological_processnegative regulation of humoral immune response
G0070050biological_processneuron cellular homeostasis
G0043065biological_processpositive regulation of apoptotic process
G0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
G0034352biological_processpositive regulation of glial cell apoptotic process
G0012501biological_processprogrammed cell death
G0051291biological_processprotein heterooligomerization
G0051260biological_processprotein homooligomerization
G0046668biological_processregulation of retinal cell programmed cell death
G0010332biological_processresponse to gamma radiation
G0042594biological_processresponse to starvation
G0033353biological_processS-adenosylmethionine cycle
G0035071biological_processsalivary gland cell autophagic cell death
G0035070biological_processsalivary gland histolysis
G1901053biological_processsarcosine catabolic process
G0007423biological_processsensory organ development
G0007291biological_processsperm individualization
G0070328biological_processtriglyceride homeostasis
H0043293cellular_componentapoptosome
H0043531molecular_functionADP binding
H0005524molecular_functionATP binding
H0050700molecular_functionCARD domain binding
H0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
H0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
H0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
H0006915biological_processapoptotic process
H0097190biological_processapoptotic signaling pathway
H0021556biological_processcentral nervous system formation
H0048813biological_processdendrite morphogenesis
H0035006biological_processmelanization defense response
H0002921biological_processnegative regulation of humoral immune response
H0070050biological_processneuron cellular homeostasis
H0043065biological_processpositive regulation of apoptotic process
H0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
H0034352biological_processpositive regulation of glial cell apoptotic process
H0012501biological_processprogrammed cell death
H0051291biological_processprotein heterooligomerization
H0051260biological_processprotein homooligomerization
H0046668biological_processregulation of retinal cell programmed cell death
H0010332biological_processresponse to gamma radiation
H0042594biological_processresponse to starvation
H0033353biological_processS-adenosylmethionine cycle
H0035071biological_processsalivary gland cell autophagic cell death
H0035070biological_processsalivary gland histolysis
H1901053biological_processsarcosine catabolic process
H0007423biological_processsensory organ development
H0007291biological_processsperm individualization
H0070328biological_processtriglyceride homeostasis
I0043293cellular_componentapoptosome
I0043531molecular_functionADP binding
I0005524molecular_functionATP binding
I0050700molecular_functionCARD domain binding
I0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
I0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
I0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
I0006915biological_processapoptotic process
I0097190biological_processapoptotic signaling pathway
I0021556biological_processcentral nervous system formation
I0048813biological_processdendrite morphogenesis
I0035006biological_processmelanization defense response
I0002921biological_processnegative regulation of humoral immune response
I0070050biological_processneuron cellular homeostasis
I0043065biological_processpositive regulation of apoptotic process
I0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
I0034352biological_processpositive regulation of glial cell apoptotic process
I0012501biological_processprogrammed cell death
I0051291biological_processprotein heterooligomerization
I0051260biological_processprotein homooligomerization
I0046668biological_processregulation of retinal cell programmed cell death
I0010332biological_processresponse to gamma radiation
I0042594biological_processresponse to starvation
I0033353biological_processS-adenosylmethionine cycle
I0035071biological_processsalivary gland cell autophagic cell death
I0035070biological_processsalivary gland histolysis
I1901053biological_processsarcosine catabolic process
I0007423biological_processsensory organ development
I0007291biological_processsperm individualization
I0070328biological_processtriglyceride homeostasis
J0043293cellular_componentapoptosome
J0043531molecular_functionADP binding
J0005524molecular_functionATP binding
J0050700molecular_functionCARD domain binding
J0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
J0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
J0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
J0006915biological_processapoptotic process
J0097190biological_processapoptotic signaling pathway
J0021556biological_processcentral nervous system formation
J0048813biological_processdendrite morphogenesis
J0035006biological_processmelanization defense response
J0002921biological_processnegative regulation of humoral immune response
J0070050biological_processneuron cellular homeostasis
J0043065biological_processpositive regulation of apoptotic process
J0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
J0034352biological_processpositive regulation of glial cell apoptotic process
J0012501biological_processprogrammed cell death
J0051291biological_processprotein heterooligomerization
J0051260biological_processprotein homooligomerization
J0046668biological_processregulation of retinal cell programmed cell death
J0010332biological_processresponse to gamma radiation
J0042594biological_processresponse to starvation
J0033353biological_processS-adenosylmethionine cycle
J0035071biological_processsalivary gland cell autophagic cell death
J0035070biological_processsalivary gland histolysis
J1901053biological_processsarcosine catabolic process
J0007423biological_processsensory organ development
J0007291biological_processsperm individualization
J0070328biological_processtriglyceride homeostasis
K0043293cellular_componentapoptosome
K0043531molecular_functionADP binding
K0005524molecular_functionATP binding
K0050700molecular_functionCARD domain binding
K0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
K0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
K0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
K0006915biological_processapoptotic process
K0097190biological_processapoptotic signaling pathway
K0021556biological_processcentral nervous system formation
K0048813biological_processdendrite morphogenesis
K0035006biological_processmelanization defense response
K0002921biological_processnegative regulation of humoral immune response
K0070050biological_processneuron cellular homeostasis
K0043065biological_processpositive regulation of apoptotic process
K0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
K0034352biological_processpositive regulation of glial cell apoptotic process
K0012501biological_processprogrammed cell death
K0051291biological_processprotein heterooligomerization
K0051260biological_processprotein homooligomerization
K0046668biological_processregulation of retinal cell programmed cell death
K0010332biological_processresponse to gamma radiation
K0042594biological_processresponse to starvation
K0033353biological_processS-adenosylmethionine cycle
K0035071biological_processsalivary gland cell autophagic cell death
K0035070biological_processsalivary gland histolysis
K1901053biological_processsarcosine catabolic process
K0007423biological_processsensory organ development
K0007291biological_processsperm individualization
K0070328biological_processtriglyceride homeostasis
L0043293cellular_componentapoptosome
L0043531molecular_functionADP binding
L0005524molecular_functionATP binding
L0050700molecular_functionCARD domain binding
L0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
L0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
L0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
L0006915biological_processapoptotic process
L0097190biological_processapoptotic signaling pathway
L0021556biological_processcentral nervous system formation
L0048813biological_processdendrite morphogenesis
L0035006biological_processmelanization defense response
L0002921biological_processnegative regulation of humoral immune response
L0070050biological_processneuron cellular homeostasis
L0043065biological_processpositive regulation of apoptotic process
L0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
L0034352biological_processpositive regulation of glial cell apoptotic process
L0012501biological_processprogrammed cell death
L0051291biological_processprotein heterooligomerization
L0051260biological_processprotein homooligomerization
L0046668biological_processregulation of retinal cell programmed cell death
L0010332biological_processresponse to gamma radiation
L0042594biological_processresponse to starvation
L0033353biological_processS-adenosylmethionine cycle
L0035071biological_processsalivary gland cell autophagic cell death
L0035070biological_processsalivary gland histolysis
L1901053biological_processsarcosine catabolic process
L0007423biological_processsensory organ development
L0007291biological_processsperm individualization
L0070328biological_processtriglyceride homeostasis
M0043293cellular_componentapoptosome
M0043531molecular_functionADP binding
M0005524molecular_functionATP binding
M0050700molecular_functionCARD domain binding
M0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
M0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
M0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
M0006915biological_processapoptotic process
M0097190biological_processapoptotic signaling pathway
M0021556biological_processcentral nervous system formation
M0048813biological_processdendrite morphogenesis
M0035006biological_processmelanization defense response
M0002921biological_processnegative regulation of humoral immune response
M0070050biological_processneuron cellular homeostasis
M0043065biological_processpositive regulation of apoptotic process
M0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
M0034352biological_processpositive regulation of glial cell apoptotic process
M0012501biological_processprogrammed cell death
M0051291biological_processprotein heterooligomerization
M0051260biological_processprotein homooligomerization
M0046668biological_processregulation of retinal cell programmed cell death
M0010332biological_processresponse to gamma radiation
M0042594biological_processresponse to starvation
M0033353biological_processS-adenosylmethionine cycle
M0035071biological_processsalivary gland cell autophagic cell death
M0035070biological_processsalivary gland histolysis
M1901053biological_processsarcosine catabolic process
M0007423biological_processsensory organ development
M0007291biological_processsperm individualization
M0070328biological_processtriglyceride homeostasis
N0043293cellular_componentapoptosome
N0043531molecular_functionADP binding
N0005524molecular_functionATP binding
N0050700molecular_functionCARD domain binding
N0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
N0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
N0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
N0006915biological_processapoptotic process
N0097190biological_processapoptotic signaling pathway
N0021556biological_processcentral nervous system formation
N0048813biological_processdendrite morphogenesis
N0035006biological_processmelanization defense response
N0002921biological_processnegative regulation of humoral immune response
N0070050biological_processneuron cellular homeostasis
N0043065biological_processpositive regulation of apoptotic process
N0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
N0034352biological_processpositive regulation of glial cell apoptotic process
N0012501biological_processprogrammed cell death
N0051291biological_processprotein heterooligomerization
N0051260biological_processprotein homooligomerization
N0046668biological_processregulation of retinal cell programmed cell death
N0010332biological_processresponse to gamma radiation
N0042594biological_processresponse to starvation
N0033353biological_processS-adenosylmethionine cycle
N0035071biological_processsalivary gland cell autophagic cell death
N0035070biological_processsalivary gland histolysis
N1901053biological_processsarcosine catabolic process
N0007423biological_processsensory organ development
N0007291biological_processsperm individualization
N0070328biological_processtriglyceride homeostasis
O0043293cellular_componentapoptosome
O0043531molecular_functionADP binding
O0005524molecular_functionATP binding
O0050700molecular_functionCARD domain binding
O0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
O0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
O0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
O0006915biological_processapoptotic process
O0097190biological_processapoptotic signaling pathway
O0021556biological_processcentral nervous system formation
O0048813biological_processdendrite morphogenesis
O0035006biological_processmelanization defense response
O0002921biological_processnegative regulation of humoral immune response
O0070050biological_processneuron cellular homeostasis
O0043065biological_processpositive regulation of apoptotic process
O0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
O0034352biological_processpositive regulation of glial cell apoptotic process
O0012501biological_processprogrammed cell death
O0051291biological_processprotein heterooligomerization
O0051260biological_processprotein homooligomerization
O0046668biological_processregulation of retinal cell programmed cell death
O0010332biological_processresponse to gamma radiation
O0042594biological_processresponse to starvation
O0033353biological_processS-adenosylmethionine cycle
O0035071biological_processsalivary gland cell autophagic cell death
O0035070biological_processsalivary gland histolysis
O1901053biological_processsarcosine catabolic process
O0007423biological_processsensory organ development
O0007291biological_processsperm individualization
O0070328biological_processtriglyceride homeostasis
P0043293cellular_componentapoptosome
P0043531molecular_functionADP binding
P0005524molecular_functionATP binding
P0050700molecular_functionCARD domain binding
P0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
P0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
P0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
P0006915biological_processapoptotic process
P0097190biological_processapoptotic signaling pathway
P0021556biological_processcentral nervous system formation
P0048813biological_processdendrite morphogenesis
P0035006biological_processmelanization defense response
P0002921biological_processnegative regulation of humoral immune response
P0070050biological_processneuron cellular homeostasis
P0043065biological_processpositive regulation of apoptotic process
P0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
P0034352biological_processpositive regulation of glial cell apoptotic process
P0012501biological_processprogrammed cell death
P0051291biological_processprotein heterooligomerization
P0051260biological_processprotein homooligomerization
P0046668biological_processregulation of retinal cell programmed cell death
P0010332biological_processresponse to gamma radiation
P0042594biological_processresponse to starvation
P0033353biological_processS-adenosylmethionine cycle
P0035071biological_processsalivary gland cell autophagic cell death
P0035070biological_processsalivary gland histolysis
P1901053biological_processsarcosine catabolic process
P0007423biological_processsensory organ development
P0007291biological_processsperm individualization
P0070328biological_processtriglyceride homeostasis
Q0043293cellular_componentapoptosome
Q0043531molecular_functionADP binding
Q0005524molecular_functionATP binding
Q0050700molecular_functionCARD domain binding
Q0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
Q0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Q0008635biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
Q0006915biological_processapoptotic process
Q0097190biological_processapoptotic signaling pathway
Q0021556biological_processcentral nervous system formation
Q0048813biological_processdendrite morphogenesis
Q0035006biological_processmelanization defense response
Q0002921biological_processnegative regulation of humoral immune response
Q0070050biological_processneuron cellular homeostasis
Q0043065biological_processpositive regulation of apoptotic process
Q0046672biological_processpositive regulation of compound eye retinal cell programmed cell death
Q0034352biological_processpositive regulation of glial cell apoptotic process
Q0012501biological_processprogrammed cell death
Q0051291biological_processprotein heterooligomerization
Q0051260biological_processprotein homooligomerization
Q0046668biological_processregulation of retinal cell programmed cell death
Q0010332biological_processresponse to gamma radiation
Q0042594biological_processresponse to starvation
Q0033353biological_processS-adenosylmethionine cycle
Q0035071biological_processsalivary gland cell autophagic cell death
Q0035070biological_processsalivary gland histolysis
Q1901053biological_processsarcosine catabolic process
Q0007423biological_processsensory organ development
Q0007291biological_processsperm individualization
Q0070328biological_processtriglyceride homeostasis
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
DTP_3j9l_C_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
CTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
CSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_D_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
DTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
DSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_E_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
ETYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
EVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
EASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ETHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
EARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ELEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ETYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
EPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ESER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_F_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
FTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
FSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_G_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
GTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
GSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_H_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
HTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_I_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
ITYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
IVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
IASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ITHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
IARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ILEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ITYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
IPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
ISER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_J_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
JTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
JSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_K_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
KTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
KSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_L_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
LTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
LSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_M_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
MTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
MSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_N_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
NTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
NSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_O_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
OTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
OSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_P_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
PTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
PSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

DTP_3j9l_Q_1301212'-DEOXYADENOSINE 5'-TRIPHOSPHATE binding site
ChainResidueligand
QTYR123-ARG127DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QVAL152-TRP159DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QASN246DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QTHR265DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QARG267DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QLEU300DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QTYR304DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QPRO321-ARG322DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
QSER325DTP: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails

> Sequence Neighbor

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