Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 124 件

4U2V
DownloadVisualize
BU of 4u2v by Molmil
Bak BH3-in-Groove dimer (GFP)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Green fluorescent protein,Bcl-2 homologous antagonist/killer
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2014-07-18
公開日2014-09-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers.
Mol.Cell, 55, 2014
3INQ
DownloadVisualize
BU of 3inq by Molmil
Crystal structure of BCL-XL in complex with W1191542
分子名称: 1,2-ETHANEDIOL, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, Bcl-2-like protein 1, ...
著者Fairlie, W.D, Smith, B.J, Colman, P.M, Czabotar, P.E, Lee, E.F.
登録日2009-08-12
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
4TUH
DownloadVisualize
BU of 4tuh by Molmil
Bcl-xL in complex with inhibitor (Compound 10)
分子名称: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid, ACETATE ION, ...
著者Czabotar, P.E, Lessense, G, Smith, B.J, Colman, P.M.
登録日2014-06-24
公開日2014-10-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Acs Med.Chem.Lett., 5, 2014
3IO9
DownloadVisualize
BU of 3io9 by Molmil
BimL12Y in complex with Mcl-1
分子名称: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
著者Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D.
登録日2009-08-14
公開日2009-09-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3PL7
DownloadVisualize
BU of 3pl7 by Molmil
Crystal structure of Bcl-xL in complex with the BaxBH3 domain
分子名称: Apoptosis regulator BAX, Bcl-2-like protein 1
著者Czabotar, P.E, Colman, P.M.
登録日2010-11-14
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.613 Å)
主引用文献Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3QBR
DownloadVisualize
BU of 3qbr by Molmil
BakBH3 in complex with sjA
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein
著者Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B.
登録日2011-01-13
公開日2011-04-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PK1
DownloadVisualize
BU of 3pk1 by Molmil
Crystal structure of Mcl-1 in complex with the BaxBH3 domain
分子名称: Apoptosis regulator BAX, CADMIUM ION, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Czabotar, P.E, Colman, P.M.
登録日2010-11-11
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.486 Å)
主引用文献Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
1YWG
DownloadVisualize
BU of 1ywg by Molmil
The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, glyceraldehyde-3-phosphate dehydrogenase
著者Satchell, J.F, Klonis, N, Malby, R.L, Adisa, A, Alpyurek, A.E, Colman, P.M, Tilley, L.
登録日2005-02-17
公開日2005-11-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
Acta Crystallogr.,Sect.D, 61, 2005
6O0L
DownloadVisualize
BU of 6o0l by Molmil
crystal structure of BCL-2 G101V mutation with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, CHLORIDE ION, ...
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-16
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0P
DownloadVisualize
BU of 6o0p by Molmil
crystal structure of BCL-2 G101A mutation with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-17
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0O
DownloadVisualize
BU of 6o0o by Molmil
crystal structure of BCL-2 G101V mutation with S55746
分子名称: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-17
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0M
DownloadVisualize
BU of 6o0m by Molmil
crystal structure of BCL-2 F104L mutation with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-16
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0K
DownloadVisualize
BU of 6o0k by Molmil
crystal structure of BCL-2 with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2, NONAETHYLENE GLYCOL
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-16
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
1V3D
DownloadVisualize
BU of 1v3d by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
登録日2003-10-30
公開日2004-02-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V2I
DownloadVisualize
BU of 1v2i by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
登録日2003-10-16
公開日2004-02-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3B
DownloadVisualize
BU of 1v3b by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
登録日2003-10-30
公開日2004-02-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3E
DownloadVisualize
BU of 1v3e by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with ZANAMAVIR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
登録日2003-10-30
公開日2004-02-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
1V3C
DownloadVisualize
BU of 1v3c by Molmil
Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Lawrence, M.C, Borg, N.A, Streltsov, V.A, Pilling, P.A, Epa, V.C, Varghese, J.N, McKimm-Breschkin, J.L, Colman, P.M.
登録日2003-10-30
公開日2004-02-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III
J.Mol.Biol., 335, 2004
8SPZ
DownloadVisualize
BU of 8spz by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with dioctanoyl phosphatidylserine
分子名称: Apoptosis regulator BAX, SULFATE ION
著者Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S.
登録日2023-05-04
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SVK
DownloadVisualize
BU of 8svk by Molmil
Crystal structure of Bax D71N core domain BH3-groove dimer
分子名称: Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Miller, M.S, Czabotar, P.E, Colman, P.M.
登録日2023-05-16
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SPF
DownloadVisualize
BU of 8spf by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ...
著者Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M.
登録日2023-05-03
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SRX
DownloadVisualize
BU of 8srx by Molmil
Crystal structure of BAK-BAX heterodimer with lysoPC
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-07
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SRY
DownloadVisualize
BU of 8sry by Molmil
Crystal structure of BAK-BAX heterodimer with C12E8
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-08
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SPE
DownloadVisualize
BU of 8spe by Molmil
Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ...
著者Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E.
登録日2023-05-03
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
2F10
DownloadVisualize
BU of 2f10 by Molmil
Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor
分子名称: 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, PHOSPHATE ION, Sialidase 2
著者Chavas, L.M.G, Kato, R, McKimm-Breschkin, J, Colman, P.M, Fusi, P, Tringali, C, Venerando, B, Tettamanti, G, Monti, E, Wakatsuki, S.
登録日2005-11-14
公開日2006-11-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor
To be Published

221716

件を2024-06-26に公開中

PDB statisticsPDBj update infoContact PDBjnumon