2YXJ

Crystal structure of Bcl-xL in complex with ABT-737

Summary for 2YXJ

• Entry DOI: 10.2210/pdb2yxj/pdb
• Related: 1AF3 1MAZ 1PQ0 1PQ1 1R2D 1YSG 1YSI 1YSN 2O1Y 2O2M 2O2N
• Descriptor: Apoptosis regulator Bcl-X, CHLORIDE ION, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, ... (5 entities in total)
• Functional Keywords: apoptosis, cancer therapeutic
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
• Total number of polymer chains: 2
• Total formula weight: 43364.24

Authors

Czabotar, P.E.,Lee, E.F.,Smith, B.J.,Deshayes, K.,Zobel, K.,Fairlie, W.D.,Colman, P.M. (deposition date: 2007-04-26, release date: 2007-05-22, Last modification date: 2023-10-25)

• Primary citation: Lee, E.F.,Czabotar, P.E.,Smith, B.J.,Deshayes, K.,Zobel, K.,Colman, P.M.,Fairlie, W.D.; Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family; Cell Death Differ., 14:1711-1713, 2007; PubMed: 17572662; DOI: 10.1038/sj.cdd.4402178

Experimental method

X-RAY DIFFRACTION (2.2 Å)