2YXJ

Crystal structure of Bcl-xL in complex with ABT-737

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Apoptosis regulator Bcl-X	polymer	181	20804.9	2	UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB	Homo sapiens (human)	Bcl-2-like 1 protein
2	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
3	A, B	4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE	non-polymer		813.4	2	Chemie (N3C)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	201	Chemie (HOH)

Sequence modifications

A, B: 1 - 84 (UniProt: Q07817)

PDB	External Database	Details
Met -3	-	expression tag
Ser -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Leu 210	-	expression tag
Glu 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	41609.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1754.4
All*	Total formula weight	43364.2

*Water molecules are not included.