2YXJ
Crystal structure of Bcl-xL in complex with ABT-737
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Apoptosis regulator Bcl-X | polymer | 181 | 20804.9 | 2 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-like 1 protein |
| 2 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | D, F (A, B) | 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE | non-polymer | 813.4 | 2 | Chemie (N3C) | |||
| 4 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 84 (UniProt: Q07817)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Leu 210 | - | expression tag |
| Glu 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
| His 215 | - | expression tag |
| His 216 | - | expression tag |
| His 217 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41609.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1754.4 | |
| All* | Total formula weight | 43364.2 |
