4ZII

Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3

Summary for 4ZII

• Entry DOI: 10.2210/pdb4zii/pdb
• Related: 4ZIE 4ZIF 4ZIG 4ZIH
• Descriptor: Apoptosis regulator BAX, BH3-interacting domain death agonist, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bax, apoptosis, bh3 domain, structural genomics
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 22826.82

Authors

Czabotar, P.E.,Robin, A.Y.,Krishna Kumar, K.,Westphal, D.,Wardak, A.Z.,Thompson, G.V.,Dewson, G.,Colman, P.M. (deposition date: 2015-04-28, release date: 2015-07-22, Last modification date: 2023-09-27)

• Primary citation: Robin, A.Y.,Krishna Kumar, K.,Westphal, D.,Wardak, A.Z.,Thompson, G.V.,Dewson, G.,Colman, P.M.,Czabotar, P.E.; Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.; Cell Death Dis, 6:e1809-e1809, 2015; PubMed: 26158515; DOI: 10.1038/cddis.2015.141

Experimental method

X-RAY DIFFRACTION (2.191 Å)