4ZII

Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
C	0005737	cellular_component	cytoplasm
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 201

Chain	Residue
A	SER55
A	THR56
A	TRP158
A	ASP159
A	HOH303

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site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 202

Chain	Residue
A	MET20
A	ARG145
A	HOH309

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site_id	AC3
Number of Residues	1
Details	binding site for residue EDO A 203

Chain	Residue
A	ASP154

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site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 204

Chain	Residue
A	LEU45
A	ALA81
A	LYS123
A	SER126
A	HOH306

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site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 205

Chain	Residue
A	PRO88
A	TRP139

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Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. MFsDGnfNWGRVVALFyFAS

Chain	Residue	Details
A	MET99-SER118

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdqGGWDgLL

Chain	Residue	Details
A	TRP151-LEU162

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site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LsesLKrIGDELDSN

Chain	Residue	Details
A	LEU59-ASN73
C	ILE86-SER100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	MET1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36361894

Chain	Residue	Details
A	LYS128

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