2YJ1

Puma BH3 foldamer in complex with Bcl-xL

Summary for 2YJ1

• Entry DOI: 10.2210/pdb2yj1/pdb
• Related: 1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48
• Descriptor: BCL-2-LIKE PROTEIN 1, ALPHA-BETA-PUMA BH3 FOLDAMER (3 entities in total)
• Functional Keywords: apoptosis, membrane protein, foldamer, bh3 domain, autophagy
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 41069.87

Authors

Lee, E.F.,Smith, B.J.,Horne, W.S.,Mayer, K.N.,Evangelista, M.,Colman, P.M.,Gellman, S.H.,Fairlie, W.D. (deposition date: 2011-05-18, release date: 2011-10-12, Last modification date: 2023-12-20)

• Primary citation: Lee, E.F.,Smith, B.J.,Horne, W.S.,Mayer, K.N.,Evangelista, M.,Colman, P.M.,Gellman, S.H.,Fairlie, W.D.; Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design; Chembiochem, 12:2025-, 2011; PubMed: 21744457; DOI: 10.1002/CBIC.201100314

Experimental method

X-RAY DIFFRACTION (2.24 Å)