2YJ1
Puma BH3 foldamer in complex with Bcl-xL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0042981 | biological_process | regulation of apoptotic process |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0090200 | biological_process | positive regulation of release of cytochrome c from mitochondria |
| B | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
| C | 0042981 | biological_process | regulation of apoptotic process |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0043065 | biological_process | positive regulation of apoptotic process |
| D | 0090200 | biological_process | positive regulation of release of cytochrome c from mitochondria |
| D | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS01080 |
| Number of Residues | 19 |
| Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG |
| Chain | Residue | Details |
| A | LEU130-GLY148 |
| site_id | PS01258 |
| Number of Residues | 12 |
| Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV |
| Chain | Residue | Details |
| A | TRP181-VAL192 |
| site_id | PS01259 |
| Number of Residues | 15 |
| Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR |
| Chain | Residue | Details |
| A | VAL86-ARG100 |
| site_id | PS01260 |
| Number of Residues | 21 |
| Details | BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW |
| Chain | Residue | Details |
| A | SER4-TRP24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by caspase-1 |
| Chain | Residue | Details |
| A | GLY117 | |
| C | GLY117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391 |
| Chain | Residue | Details |
| A | PHE105 | |
| C | PHE105 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720 |
| Chain | Residue | Details |
| A | THR118 | |
| C | THR118 |
