6O0O
crystal structure of BCL-2 G101V mutation with S55746
Summary for 6O0O
Entry DOI | 10.2210/pdb6o0o/pdb |
Descriptor | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide (3 entities in total) |
Functional Keywords | bcl-2, s55746, complex, protein-protein interface inhibitor, resistance mutation, apoptosis |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 40220.91 |
Authors | Birkinshaw, R.W.,Luo, C.S.,Colman, P.M.,Czabotar, P.E. (deposition date: 2019-02-17, release date: 2019-05-22, Last modification date: 2023-10-11) |
Primary citation | Birkinshaw, R.W.,Gong, J.N.,Luo, C.S.,Lio, D.,White, C.A.,Anderson, M.A.,Blombery, P.,Lessene, G.,Majewski, I.J.,Thijssen, R.,Roberts, A.W.,Huang, D.C.S.,Colman, P.M.,Czabotar, P.E. Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10:2385-2385, 2019 Cited by PubMed: 31160589DOI: 10.1038/s41467-019-10363-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.998 Å) |
Structure validation
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