6O0O
crystal structure of BCL-2 G101V mutation with S55746
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2 | polymer | 166 | 19399.6 | 2 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
| 2 | C, D (A, C) | ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | non-polymer | 710.8 | 2 | Chemie (F3Q) | |||
| 3 | E, F (A, C) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 34 (UniProt: P10415)
A, C: 35 - 50 (UniProt: Q07817)
A, C: 51 - 166 (UniProt: P10415)
A, C: 35 - 50 (UniProt: Q07817)
A, C: 51 - 166 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Val 60 | Gly 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38799.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1421.6 | |
| All* | Total formula weight | 40220.9 |
