6O0O

crystal structure of BCL-2 G101V mutation with S55746

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue F3Q A 201

Chain	Residue
A	PHE63
A	GLY104
A	ARG105
A	ALA108
A	PHE112
A	TYR67
A	ASP70
A	PHE71
A	MET74
A	ARG88
A	VAL92
A	GLU95
A	LEU96

---

site_id	AC2
Number of Residues	12
Details	binding site for residue F3Q C 201

Chain	Residue
C	PHE63
C	TYR67
C	ASP70
C	MET74
C	VAL92
C	GLU95
C	LEU96
C	GLY104
C	ARG105
C	ALA108
C	GLU111
C	PHE112

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU96-GLY114

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP147-VAL158

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP10-TRP30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---