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PDB: 125 件
6O0M
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BU of 6o0m by Molmil
crystal structure of BCL-2 F104L mutation with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-16
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
6O0K
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crystal structure of BCL-2 with venetoclax
分子名称: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2, NONAETHYLENE GLYCOL
著者Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E.
登録日2019-02-16
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Nat Commun, 10, 2019
8SPE
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BU of 8spe by Molmil
Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P31
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, ...
著者Miller, M.S, Cowan, A.D, Colman, P.M, Czabotar, P.E.
登録日2023-05-03
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SPF
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BU of 8spf by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with 2-stearoyl lysoPC
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, DODECANE, ...
著者Cowan, A.D, Miller, M.S, Czabotar, P.E, Colman, P.M.
登録日2023-05-03
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
3PK1
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BU of 3pk1 by Molmil
Crystal structure of Mcl-1 in complex with the BaxBH3 domain
分子名称: Apoptosis regulator BAX, CADMIUM ION, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Czabotar, P.E, Colman, P.M.
登録日2010-11-11
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.486 Å)
主引用文献Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
8SRX
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BU of 8srx by Molmil
Crystal structure of BAK-BAX heterodimer with lysoPC
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-07
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
3PL7
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BU of 3pl7 by Molmil
Crystal structure of Bcl-xL in complex with the BaxBH3 domain
分子名称: Apoptosis regulator BAX, Bcl-2-like protein 1
著者Czabotar, P.E, Colman, P.M.
登録日2010-11-14
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.613 Å)
主引用文献Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3QBR
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BU of 3qbr by Molmil
BakBH3 in complex with sjA
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein
著者Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B.
登録日2011-01-13
公開日2011-04-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
8SPZ
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BU of 8spz by Molmil
Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with dioctanoyl phosphatidylserine
分子名称: Apoptosis regulator BAX, SULFATE ION
著者Cowan, A.D, Colman, P.M, Czabotar, P.E, Miller, M.S.
登録日2023-05-04
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SVK
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BU of 8svk by Molmil
Crystal structure of Bax D71N core domain BH3-groove dimer
分子名称: Apoptosis regulator BAX, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Miller, M.S, Czabotar, P.E, Colman, P.M.
登録日2023-05-16
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
8SRY
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BU of 8sry by Molmil
Crystal structure of BAK-BAX heterodimer with C12E8
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ...
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S.
登録日2023-05-08
公開日2023-12-27
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
分子名称: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
著者Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
登録日2008-05-22
公開日2008-06-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
5VWV
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BU of 5vwv by Molmil
Bak core latch dimer in complex with Bim-BH3 - Cubic
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX2
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BU of 5vx2 by Molmil
Mcl-1 in complex with Bim-h3Pc-RT
分子名称: 1,2-ETHANEDIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera
著者Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX1
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BU of 5vx1 by Molmil
Bak L100A
分子名称: Bcl-2 homologous antagonist/killer
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.224 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX0
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BU of 5vx0 by Molmil
Bak in complex with Bim-h3Glg
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
著者Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWW
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BU of 5vww by Molmil
Bak core latch dimer in complex with Bim-RT - Tetragonal
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BROMIDE ION, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
2YXJ
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BU of 2yxj by Molmil
Crystal structure of Bcl-xL in complex with ABT-737
分子名称: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, Apoptosis regulator Bcl-X, CHLORIDE ION, ...
著者Czabotar, P.E, Lee, E.F, Smith, B.J, Deshayes, K, Zobel, K, Fairlie, W.D, Colman, P.M.
登録日2007-04-26
公開日2007-05-22
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
3FDM
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BU of 3fdm by Molmil
alpha/beta foldamer in complex with Bcl-xL
分子名称: 1,2-ETHANEDIOL, Apoptosis regulator Bcl-X, alpha/beta-peptide foldamer
著者Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M, Sadowsky, J.D, Peterson-Kaufman, K.J, Gellman, S.H.
登録日2008-11-26
公開日2009-03-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
5WDD
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BU of 5wdd by Molmil
Crystal structure of chicken BOK
分子名称: 1,2-ETHANEDIOL, Bcl-2-related ovarian killer protein
著者Cowan, A.D, Colman, P.M, Czabotar, P.E.
登録日2017-07-04
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Cell, 173, 2018
3FDL
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BU of 3fdl by Molmil
Bim BH3 peptide in complex with Bcl-xL
分子名称: Apoptosis regulator Bcl-X, Bcl-2-like protein 11
著者Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
登録日2008-11-26
公開日2009-03-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
1PHS
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BU of 1phs by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF THE SEED STORAGE PROTEIN PHASEOLIN AT 3 ANGSTROMS RESOLUTION
分子名称: PHASEOLIN, BETA-TYPE PRECURSOR
著者Lawrence, M.C, Suzuki, E, Varghese, J.N, Davis, P.C, Vandonkelaar, A, Tulloch, P.A, Colman, P.M.
登録日1990-03-21
公開日1990-10-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.
EMBO J., 9, 1990
6UXP
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BU of 6uxp by Molmil
Crystal structure of BAK core domain BH3-groove-dimer in complex with phosphatidylglycerol
分子名称: 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL), Bcl-2 homologous antagonist/killer, GLYCEROL
著者Cowan, A.D, Colman, P.M, Czabotar, P.E.
登録日2019-11-07
公開日2020-09-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.492 Å)
主引用文献BAK core dimers bind lipids and can be bridged by them.
Nat.Struct.Mol.Biol., 27, 2020
6UXM
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Crystal structure of BAK core domain BH3-groove-dimer in complex with E. coli lipid
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Bcl-2 homologous antagonist/killer
著者Cowan, A.D, Colman, P.M, Czabotar, P.E.
登録日2019-11-07
公開日2020-09-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献BAK core dimers bind lipids and can be bridged by them.
Nat.Struct.Mol.Biol., 27, 2020
3ZLN
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BU of 3zln by Molmil
Crystal structure of BCL-XL in complex with inhibitor (Compound 3)
分子名称: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ...
著者Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M.
登録日2013-02-04
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.288 Å)
主引用文献Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013

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