6UXP

Crystal structure of BAK core domain BH3-groove-dimer in complex with phosphatidylglycerol

Summary for 6UXP

• Entry DOI: 10.2210/pdb6uxp/pdb
• Descriptor: Bcl-2 homologous antagonist/killer, 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL), GLYCEROL, ... (4 entities in total)
• Functional Keywords: pore-forming protein, apoptosis
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 80354.18

Authors

Cowan, A.D.,Colman, P.M.,Czabotar, P.E. (deposition date: 2019-11-07, release date: 2020-09-02, Last modification date: 2023-10-11)

• Primary citation: Cowan, A.D.,Smith, N.A.,Sandow, J.J.,Kapp, E.A.,Rustam, Y.H.,Murphy, J.M.,Brouwer, J.M.,Bernardini, J.P.,Roy, M.J.,Wardak, A.Z.,Tan, I.K.,Webb, A.I.,Gulbis, J.M.,Smith, B.J.,Reid, G.E.,Dewson, G.,Colman, P.M.,Czabotar, P.E.; BAK core dimers bind lipids and can be bridged by them.; Nat.Struct.Mol.Biol., 27:1024-1031, 2020; PubMed: 32929280; DOI: 10.1038/s41594-020-0494-5

Experimental method

X-RAY DIFFRACTION (2.492 Å)