5WDD
Crystal structure of chicken BOK
Summary for 5WDD
| Entry DOI | 10.2210/pdb5wdd/pdb |
| Descriptor | Bcl-2-related ovarian killer protein, 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | bcl-2, apoptosis, pro-apoptotic, cell death |
| Biological source | Gallus gallus (Chicken) |
| Total number of polymer chains | 2 |
| Total formula weight | 37098.86 |
| Authors | Cowan, A.D.,Colman, P.M.,Czabotar, P.E. (deposition date: 2017-07-04, release date: 2018-02-28, Last modification date: 2023-10-04) |
| Primary citation | Ke, F.F.S.,Vanyai, H.K.,Cowan, A.D.,Delbridge, A.R.D.,Whitehead, L.,Grabow, S.,Czabotar, P.E.,Voss, A.K.,Strasser, A. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell, 173:1217-1230.e17, 2018 Cited by PubMed Abstract: Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our structural analysis of BOK suggests close resemblance to BAX and BAK structures. Notably, BokBaxBak animals exhibited more severe defects and died earlier than BaxBak mice, implying that BOK has overlapping roles with BAX and BAK during developmental cell death. By analyzing BokBaxBak triple-knockout mice whose cells are incapable of undergoing intrinsic apoptosis, we identified tissues that formed well without this process. We provide evidence that necroptosis, pyroptosis, or autophagy does not substantially substitute for the loss of apoptosis. Albeit very rare, unexpected attainment of adult BokBaxBak mice suggests that morphogenesis can proceed entirely without apoptosis mediated by these proteins and possibly without cell death in general. PubMed: 29775594DOI: 10.1016/j.cell.2018.04.036 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.799 Å) |
Structure validation
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