3ZLN

Crystal structure of BCL-XL in complex with inhibitor (Compound 3)

Summary for 3ZLN

Entry DOI	10.2210/pdb3zln/pdb
Related	3ZK6 3ZLO 3ZLR
Descriptor	BCL-2-LIKE PROTEIN 1, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	apoptosis, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	21625.80
Authors	Czabotar, P.E.,Lessene, G.L.,Smith, B.J.,Colman, P.M. (deposition date: 2013-02-04, release date: 2013-04-24, Last modification date: 2023-12-20)
Primary citation	Lessene, G.L.,Czabotar, P.E.,Sleebs, B.E.,Zobel, K.,Lowes, K.L.,Adams, J.M.,Baell, J.B.,Colman, P.M.,Deshayes, K.,Fairbrother, W.J.,Flygare, J.A.,Gibbons, P.,Kersten, W.J.A.,Kulasegaram, S.,Moss, R.M.,Parisot, J.P.,Smith, B.J.,Street, I.P.,Yang, H.,Huang, D.C.S.,Watson, K.G. Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9:390-397, 2013 Cited by PubMed: 23603658 DOI: 10.1038/NCHEMBIO.1246 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.288 Å)

Structure validation