3ZK6
Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).
Summary for 3ZK6
Entry DOI | 10.2210/pdb3zk6/pdb |
Related | 3ZLN 3ZLO 3ZLR |
Descriptor | BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide (3 entities in total) |
Functional Keywords | apoptosis, inhibitor, bcl-2 family |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion membrane; Single-pass membrane protein: Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 42715.56 |
Authors | Czabotar, P.E.,Lessene, G.L.,Smith, B.J.,Colman, P.M. (deposition date: 2013-01-22, release date: 2013-04-24, Last modification date: 2023-12-20) |
Primary citation | Lessene, G.L.,Czabotar, P.E.,Sleebs, B.E.,Zobel, K.,Lowes, K.L.,Adams, J.M.,Baell, J.B.,Colman, P.M.,Deshayes, K.,Fairbrother, W.J.,Flygare, J.A.,Gibbons, P.,Kersten, W.J.A.,Kulasegaram, S.,Moss, R.M.,Parisot, J.P.,Smith, B.J.,Street, I.P.,Yang, H.,Huang, D.C.S.,Watson, K.G. Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9:390-, 2013 Cited by PubMed: 23603658DOI: 10.1038/NCHEMBIO.1246 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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